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Target Report Card

Target Name and Classification

Target ID CHEMBL2292
Preferred Name Dual-specificity tyrosine-phosphorylation regulated kinase 1A
Synonyms DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | HP86 | MNB | MNBH | MNBH | Protein kinase minibrain homolog | hMNB
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase dyrk family > cmgc protein kinase dyrk1 subfamily

Target Components

Component Description Relationship Accession
Dual specificity tyrosine-phosphorylation-regulated kinase 1A SINGLE PROTEIN Q13627

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000157540
Ensembl ENSG00000157540
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005856 (cytoskeleton)
GO:0005874 (microtubule)
GO:0005883 (neurofilament)
GO:0005884 (actin filament)
GO:0016607 (nuclear speck)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003779 (actin binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008092 (cytoskeletal protein binding)
GO:0015631 (tubulin binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042802 (identical protein binding)
GO:0043621 (protein self-association)
GO:0048156 (tau protein binding)
GO Biological Process GO:0000381 (regulation of alternative mRNA splicing, via spliceosome)
GO:0006468 (protein phosphorylation)
GO:0007399 (nervous system development)
GO:0007623 (circadian rhythm)
GO:0016032 (viral process)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0031115 (negative regulation of microtubule polymerization)
GO:0033120 (positive regulation of RNA splicing)
GO:0034205 (beta-amyloid formation)
GO:0036289 (peptidyl-serine autophosphorylation)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0043518 (negative regulation of DNA damage response, signal transduction by p53 class mediator)
GO:0046777 (protein autophosphorylation)
GO:0048025 (negative regulation of mRNA splicing, via spliceosome)
GO:0090312 (positive regulation of protein deacetylation)
Wikipedia DYRK1A

Target Cross References - Protein

canSAR Q13627
CGD Mental retardation, autosomal dominant 7
Human Protein Atlas ENSG00000157540
IntAct Q13627
Guide to Pharmacology 2009
Open Targets ENSG00000157540
PharmGKB PA27545
Pharos Q13627 (Tchem)
Reactome R-HSA-1538133 (G0 and Early G1.)
UniProt O60769 Q13627 Q92582 Q92810 Q9UNM5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR028318 (DYRK1A/MNB.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2VX3 2WO6 3ANQ 3ANR 4AZE 4MQ1 4MQ2 4NCT 4YLJ 4YLK 4YLL 4YU2 5A3X 5A4E 5A4L 5A4Q 5A4T 5A54 5AIK
CREDO 2VX3 2WO6 3ANQ 3ANR 4AZE 4MQ1 4MQ2 4NCT 4YLJ 4YLK 4YLL 4YU2 5A3X 5A4E 5A4L 5A4Q 5A4T 5A54 5AIK