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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2274
Target Type SINGLE PROTEIN
Preferred Name Sphingosine 1-phosphate receptor Edg-8
Synonyms EDG8 | Endothelial differentiation G-protein-coupled receptor 8 | S1P receptor 5 | S1P receptor Edg-8 | S1P5 | S1PR5 | Sphingosine 1-phosphate receptor 5 | Sphingosine 1-phosphate receptor Edg-8
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > edg receptor

Target Components

Component Description Relationship Accession
Sphingosine 1-phosphate receptor 5 SINGLE PROTEIN Q9H228

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363041 Sphingosine 1-phosphate receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2336071 SIPONIMOD Sphingosine 1-phosphate receptor Edg-8 agonist 3 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000180739
Ensembl ENSG00000180739
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0038036 (sphingosine-1-phosphate receptor activity)
GO Biological Process GO:0003376 (sphingosine-1-phosphate signaling pathway)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0045664 (regulation of neuron differentiation)
Wikipedia S1PR5

Target Cross References - Protein

canSAR Q9H228
Human Protein Atlas ENSG00000180739
IntAct Q9H228
Guide to Pharmacology 279
Open Targets ENSG00000180739
PharmGKB PA162402378
Pharos Q9H228 (Tclin)
Reactome R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-419408 (Lysosphingolipid and LPA receptors.)
UniProt Q6NW11 Q9H228

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR004061 (S1P_rcpt.)
IPR005386 (EDG8_S1P_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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