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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL223
Target Type SINGLE PROTEIN
Preferred Name Alpha-1d adrenergic receptor
Synonyms ADRA1A | ADRA1D | Alpha-1A adrenergic receptor | Alpha-1D adrenergic receptor | Alpha-1D adrenoceptor | Alpha-1D adrenoreceptor | Alpha-adrenergic receptor 1a
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Alpha-1D adrenergic receptor SINGLE PROTEIN P25100

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094251 Adrenergic receptor alpha-1 PROTEIN FAMILY
CHEMBL2331074 Adrenergic receptor PROTEIN FAMILY
CHEMBL2095203 Adrenergic receptor alpha PROTEIN FAMILY
CHEMBL2111467 Alpha adrenergic receptor (1a and 1d) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171873
Ensembl ENSG00000171873
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004937 (alpha1-adrenergic receptor activity)
GO:0005515 (protein binding)
GO Biological Process GO:0001994 (norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)
GO:0006259 (DNA metabolic process)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007267 (cell-cell signaling)
GO:0007275 (multicellular organism development)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
Wikipedia Alpha-1D_adrenergic_receptor

Target Cross References - Protein

canSAR P25100
Human Protein Atlas ENSG00000171873
IntAct P25100
Guide to Pharmacology 24
Open Targets ENSG00000171873
PharmGKB PA24597
Pharos P25100 (Tclin)
Reactome R-HSA-390696 (Adrenoceptors.)
R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-416482 (G alpha (12/13) signalling events.)
UniProt P25100 Q9NPY0

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000363 (ADRA1D_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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