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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL223
Target Type SINGLE PROTEIN
Preferred Name Alpha-1d adrenergic receptor
Synonyms ADRA1A | ADRA1D | Alpha-1A adrenergic receptor | Alpha-1D adrenergic receptor | Alpha-1D adrenoceptor | Alpha-1D adrenoreceptor | Alpha-adrenergic receptor 1a
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Alpha-1D adrenergic receptor SINGLE PROTEIN P25100

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111467 Alpha adrenergic receptor (1a and 1d) SELECTIVITY GROUP
CHEMBL2094251 Adrenergic receptor alpha-1 PROTEIN FAMILY
CHEMBL2095203 Adrenergic receptor alpha PROTEIN FAMILY
CHEMBL2331074 Adrenergic receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171873
Ensembl ENSG00000171873
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004937 (alpha1-adrenergic receptor activity)
GO:0005515 (protein binding)
GO Biological Process GO:0001994 (norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)
GO:0006259 (DNA metabolic process)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007267 (cell-cell signaling)
GO:0007275 (multicellular organism development)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
Wikipedia Alpha-1D_adrenergic_receptor

Target Cross References - Protein

canSAR P25100
Human Protein Atlas ENSG00000171873
IntAct P25100
Guide to Pharmacology 24
Open Targets ENSG00000171873
PharmGKB PA24597
Pharos P25100 (Tclin)
Reactome R-HSA-390696 (Adrenoceptors.)
R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-416482 (G alpha (12/13) signalling events.)
UniProt P25100 Q9NPY0

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000363 (ADRA1D_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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