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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL223
Target Type SINGLE PROTEIN
Preferred Name Alpha-1d adrenergic receptor
Synonyms ADRA1A | ADRA1D | Alpha-1A adrenergic receptor | Alpha-1D adrenergic receptor | Alpha-1D adrenoceptor | Alpha-1D adrenoreceptor | Alpha-adrenergic receptor 1a
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Alpha-1D adrenergic receptor SINGLE PROTEIN P25100

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094251 Adrenergic receptor alpha-1 PROTEIN FAMILY
CHEMBL2331074 Adrenergic receptor PROTEIN FAMILY
CHEMBL2095203 Adrenergic receptor alpha PROTEIN FAMILY
CHEMBL2111467 Alpha adrenergic receptor (1a and 1d) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171873
Ensembl ENSG00000171873
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0004937 (alpha1-adrenergic receptor activity)
GO Biological Process GO:0006259 (DNA metabolic process)
GO:0007188 (G-protein signaling, coupled to cAMP nucleotide second messenger)
GO:0007267 (cell-cell signaling)
GO:0007275 (multicellular organismal development)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
Wikipedia Alpha-1D_adrenergic_receptor

Target Cross References - Protein

canSAR P25100
Human Protein Atlas ENSG00000171873
IntAct P25100
Guide to Pharmacology 24 (Alpha;1D-adrenoceptor)
PharmGKB PA24597
Reactome REACT_14797 (Signaling by GPCR.)
UniProt P25100 Q9NPY0

Target Cross References - Domain

InterPro IPR000276 (7TM_GPCR_Rhodpsn.)
IPR000363 (Adren_rcpt_A1A.)
IPR002233 (Adrnrgc_rcpt.)
IPR017452 (GPCR_Rhodpsn_supfam.)
Pfam PF00001 (7tm_1)
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