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Target Report Card

Target Name and Classification

Target ID CHEMBL221
Preferred Name Cyclooxygenase-1
Synonyms COX-1 | COX1 | Cyclooxygenase-1 | PGH synthase 1 | PGHS-1 | PHS 1 | PTGS1 | Prostaglandin G/H synthase 1 | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Prostaglandin G/H synthase 1 SINGLE PROTEIN P23219

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094253 Cyclooxygenase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000095303
Ensembl ENSG00000095303
GO Cellular Component GO:0001750 (photoreceptor outer segment)
GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005794 (Golgi apparatus)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004601 (peroxidase activity)
GO:0004666 (prostaglandin-endoperoxide synthase activity)
GO:0008289 (lipid binding)
GO:0016491 (oxidoreductase activity)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0051213 (dioxygenase activity)
GO Biological Process GO:0001516 (prostaglandin biosynthetic process)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006693 (prostaglandin metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0006954 (inflammatory response)
GO:0006979 (response to oxidative stress)
GO:0007568 (aging)
GO:0007612 (learning)
GO:0007613 (memory)
GO:0008217 (regulation of blood pressure)
GO:0010243 (response to organonitrogen compound)
GO:0010700 (negative regulation of norepinephrine secretion)
GO:0019233 (sensory perception of pain)
GO:0019371 (cyclooxygenase pathway)
GO:0032811 (negative regulation of epinephrine secretion)
GO:0035633 (maintenance of blood-brain barrier)
GO:0042127 (regulation of cell proliferation)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0051412 (response to corticosterone)
GO:0055114 (oxidation-reduction process)
GO:0070542 (response to fatty acid)
GO:0098869 (cellular oxidant detoxification)
Wikipedia PTGS1

Target Cross References - Protein

Human Protein Atlas ENSG00000095303
IntAct P23219
Guide to Pharmacology 1375
Open Targets ENSG00000095303
PharmGKB PA24346
Reactome R-HSA-140180 (COX reactions.)
R-HSA-2162123 (Synthesis of Prostaglandins (PG) and Thromboxanes (TX).)
UniProt A8K1V7 B4DHQ2 B4E2S5 P23219 Q15122 Q3HY28 Q3HY29 Q5T7T6 Q5T7T7 Q5T7T8

Target Cross References - Domain

InterPro IPR000742 (EGF-like_dom.)
IPR010255 (Haem_peroxidase.)
IPR019791 (Haem_peroxidase_animal.)
IPR029580 (COX-1.)
Pfam PF00008 (EGF)
PF03098 (An_peroxidase)