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Target Report Card

Target Name and Classification

Target ID CHEMBL220
Preferred Name Acetylcholinesterase
Synonyms ACHE | AChE | Acetylcholinesterase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Acetylcholinesterase SINGLE PROTEIN P22303

Target Relations

ChEMBL ID Pref Name Target Type

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL278819 MINAPRINE Acetylcholinesterase inhibitor 4 PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed
CHEMBL748 PRALIDOXIME CHLORIDE Acetylcholinesterase activator 4 DailyMed KEGG
CHEMBL812 PYRIDOSTIGMINE BROMIDE Acetylcholinesterase inhibitor 4 DailyMed
CHEMBL1025 ISOFLUROPHATE Acetylcholinesterase inhibitor 4 PubMed PubMed
CHEMBL1128 EDROPHONIUM CHLORIDE Acetylcholinesterase inhibitor 4 DailyMed
CHEMBL211471 NEOSTIGMINE METHYLSULFATE Acetylcholinesterase inhibitor 4 DailyMed
CHEMBL1555 GALANTAMINE HYDROBROMIDE Acetylcholinesterase inhibitor 4 DailyMed
CHEMBL1678 DONEPEZIL HYDROCHLORIDE Acetylcholinesterase inhibitor 4 DailyMed
CHEMBL1200367 ECHOTHIOPHATE IODIDE Acetylcholinesterase inhibitor 4 DailyMed
CHEMBL1200514 DEMECARIUM BROMIDE Acetylcholinesterase inhibitor 4 PubMed
CHEMBL1200541 AMBENONIUM CHLORIDE Acetylcholinesterase inhibitor 4 FDA
CHEMBL1200933 HEXAFLUORENIUM BROMIDE Acetylcholinesterase inhibitor 4 PubMed PubMed
CHEMBL1201341 ECHOTHIOPHATE Acetylcholinesterase inhibitor 4 FDA
CHEMBL1364551 MINAPRINE HYDROCHLORIDE Acetylcholinesterase inhibitor 4 PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed
CHEMBL2105345 PROPANIDID Acetylcholinesterase inhibitor 4 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000087085
Ensembl ENSG00000087085
GO Cellular Component GO:0005576 (extracellular region)
GO:0005605 (basal lamina)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0030054 (cell junction)
GO:0031225 (anchored component of membrane)
GO:0031594 (neuromuscular junction)
GO:0043083 (synaptic cleft)
GO:0045202 (synapse)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0001540 (beta-amyloid binding)
GO:0003990 (acetylcholinesterase activity)
GO:0004104 (cholinesterase activity)
GO:0005515 (protein binding)
GO:0005518 (collagen binding)
GO:0016787 (hydrolase activity)
GO:0017171 (serine hydrolase activity)
GO:0042166 (acetylcholine binding)
GO:0042803 (protein homodimerization activity)
GO:0043236 (laminin binding)
GO:0043621 (protein self-association)
GO:0052689 (carboxylic ester hydrolase activity)
GO Biological Process GO:0001507 (acetylcholine catabolic process in synaptic cleft)
GO:0001919 (regulation of receptor recycling)
GO:0002076 (osteoblast development)
GO:0006260 (DNA replication)
GO:0006581 (acetylcholine catabolic process)
GO:0006656 (phosphatidylcholine biosynthetic process)
GO:0007155 (cell adhesion)
GO:0007399 (nervous system development)
GO:0007416 (synapse assembly)
GO:0007517 (muscle organ development)
GO:0008283 (cell proliferation)
GO:0009611 (response to wounding)
GO:0031623 (receptor internalization)
GO:0032223 (negative regulation of synaptic transmission, cholinergic)
GO:0042135 (neurotransmitter catabolic process)
GO:0042136 (neurotransmitter biosynthetic process)
GO:0042982 (amyloid precursor protein metabolic process)
GO:0045212 (neurotransmitter receptor biosynthetic process)
GO:0050714 (positive regulation of protein secretion)
GO:0051262 (protein tetramerization)
GO:0060041 (retina development in camera-type eye)
Wikipedia Acetylcholinesterase

Target Cross References - Protein

canSAR P22303
CGD Blood group, Yt system
Human Protein Atlas ENSG00000087085
IntAct P22303
Guide to Pharmacology 2465
MICAD NBK23068 (Acetylcholinesterase (AChE))
NBK23629 (Acetylcholinesterase (AChE))
Open Targets ENSG00000087085
PharmGKB PA20
Reactome R-HSA-112311 (Neurotransmitter clearance.)
R-HSA-1483191 (Synthesis of PC.)
R-HSA-422085 (Synthesis, secretion, and deacylation of Ghrelin.)
UniProt A4D2E2 B7ZKZ0 D6W5X7 P22303 Q16169 Q29S23 Q2M324 Q504V3 Q53F46 Q86TM9 Q86YX9 Q9BXP7

Target Cross References - Domain

InterPro IPR000997 (Cholinesterase.)
IPR002018 (CarbesteraseB.)
IPR014788 (AChE_tetra.)
IPR019819 (Carboxylesterase_B_CS.)
IPR019826 (Carboxylesterase_B_AS.)
IPR029058 (AB_hydrolase.)
Pfam PF00135 (COesterase)
PF08674 (AChE_tetra)

Target Cross References - Structure

PDBe 1B41 1F8U 1VZJ 2X8B 3LII 4BDT 4EY4 4EY5 4EY6 4EY7 4EY8 4M0E 4M0F 4PQE 5FOQ 5FPQ 5HF5 5HF6 5HF8 5HF9 5HFA
CREDO 1B41 1F8U 1VZJ 2X8B 3LII 4BDT 4EY4 4EY5 4EY6 4EY7 4EY8 4M0E 4M0F 4PQE 5FOQ 5FPQ 5HF5 5HF6 5HF8 5HF9 5HFA