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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL219
Target Type SINGLE PROTEIN
Preferred Name Dopamine D4 receptor
Synonyms D(2C) dopamine receptor | D(4) dopamine receptor | DRD4 | Dopamine D4 receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > dopamine receptor

Target Components

Component Description Relationship Accession
D(4) dopamine receptor SINGLE PROTEIN P21917

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095396 Dopamine receptors; D2 & D4 SELECTIVITY GROUP
CHEMBL2331075 D2-like dopamine receptor PROTEIN FAMILY
CHEMBL2096905 Dopamine receptor PROTEIN FAMILY
CHEMBL2097165 Dopamine receptors; D3 & D4 SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL304902 CLOTHIAPINE Dopamine D4 receptor antagonist 4 Other PubMed PubMed PubMed PubMed PubMed
CHEMBL2146110 SARIZOTAN HYDROCHLORIDE Dopamine D4 receptor agonist 3 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000069696
Ensembl ENSG00000069696
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0098794 (postsynapse)
GO Molecular Function GO:0001591 (dopamine neurotransmitter receptor activity, coupled via Gi/Go)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004952 (dopamine neurotransmitter receptor activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0015459 (potassium channel regulator activity)
GO:0017124 (SH3 domain binding)
GO:0035240 (dopamine binding)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO:0051379 (epinephrine binding)
GO:0051380 (norepinephrine binding)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0001662 (behavioral fear response)
GO:0001975 (response to amphetamine)
GO:0006874 (cellular calcium ion homeostasis)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007195 (adenylate cyclase-inhibiting dopamine receptor signaling pathway)
GO:0007212 (dopamine receptor signaling pathway)
GO:0008344 (adult locomotory behavior)
GO:0032417 (positive regulation of sodium:proton antiporter activity)
GO:0033674 (positive regulation of kinase activity)
GO:0034776 (response to histamine)
GO:0035176 (social behavior)
GO:0042053 (regulation of dopamine metabolic process)
GO:0042417 (dopamine metabolic process)
GO:0042596 (fear response)
GO:0042752 (regulation of circadian rhythm)
GO:0048148 (behavioral response to cocaine)
GO:0048149 (behavioral response to ethanol)
GO:0048511 (rhythmic process)
GO:0050482 (arachidonic acid secretion)
GO:0050709 (negative regulation of protein secretion)
GO:0051586 (positive regulation of dopamine uptake involved in synaptic transmission)
GO:0060080 (inhibitory postsynaptic potential)
GO:1901386 (negative regulation of voltage-gated calcium channel activity)
Wikipedia Dopamine_receptor_D4

Target Cross References - Protein

canSAR P21917
Human Protein Atlas ENSG00000069696
IntAct P21917
Guide to Pharmacology 217
Open Targets ENSG00000069696
PharmGKB PA27480
Pharos P21917 (Tchem)
Reactome R-HSA-390651 (Dopamine receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt B0M0J7 P21917 Q7Z7Q5 Q8NGM5

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000929 (Dopamine_rcpt.)
IPR002185 (Dopamine_D4_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 5WIU 5WIV
CREDO 5WIU 5WIV
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