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Target Report Card

Target Name and Classification

Target ID CHEMBL2169736
Target Type SINGLE PROTEIN
Preferred Name Tyrosyl-DNA phosphodiesterase 2
Synonyms 5'-Tyr-DNA phosphodiesterase | 5'-tyrosyl-DNA phosphodiesterase | EAP2 | EAPII | ETS1-associated protein 2 | ETS1-associated protein II | TDP2 | TRAF and TNF receptor-associated protein | TTRAP | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | Tyrosyl-RNA phosphodiesterase | VPg unlinkase | hTDP2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Tyrosyl-DNA phosphodiesterase 2 SINGLE PROTEIN O95551

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111802
Ensembl ENSG00000111802
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0016235 (aggresome)
GO:0016604 (nuclear body)
GO:0016605 (PML body)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0003697 (single-stranded DNA binding)
GO:0003714 (transcription corepressor activity)
GO:0004518 (nuclease activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0030145 (manganese ion binding)
GO:0036317 (tyrosyl-RNA phosphodiesterase activity)
GO:0046872 (metal ion binding)
GO:0070260 (5'-tyrosyl-DNA phosphodiesterase activity)
GO Biological Process GO:0006281 (DNA repair)
GO:0006302 (double-strand break repair)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007166 (cell surface receptor signaling pathway)
GO:0048666 (neuron development)
GO:0090305 (nucleic acid phosphodiester bond hydrolysis)
GO:1903507 (negative regulation of nucleic acid-templated transcription)

Target Cross References - Protein

Human Protein Atlas ENSG00000111802
IntAct O95551
Open Targets ENSG00000111802
PharmGKB PA165618310
Reactome R-HSA-5693571 (Nonhomologous End-Joining (NHEJ).)
UniProt B4DKL8 B4DQ95 O95551 Q2TBE2 Q5JYM0 Q7Z6U5 Q9NUK5 Q9NYY9

Target Cross References - Domain

InterPro IPR005135 (Endo/exonuclease/phosphatase.)
IPR009060 (UBA-like_sf.)
IPR036691 (Endo/exonu/phosph_ase_sf.)
Pfam PF03372 (Exo_endo_phos)

Target Cross References - Structure

PDBe 5INO 5J3P 5J3S
CREDO 5INO 5J3P 5J3S
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