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Target Report Card

Target Name and Classification

Target ID CHEMBL2128
Target Type SINGLE PROTEIN
Preferred Name Peroxisome proliferator-activated receptor alpha
Synonyms Nr1c1 | Nuclear receptor subfamily 1 group C member 1 | PPAR-alpha | Peroxisome proliferator-activated receptor alpha | Ppar | Ppara
Organism Mus musculus
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group c > nuclear hormone receptor subfamily 1 group c member 1

Target Components

Component Description Relationship Accession
Peroxisome proliferator-activated receptor alpha SINGLE PROTEIN P23204

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001078 (transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001103 (RNA polymerase II repressing transcription factor binding)
GO:0001190 (transcriptional activator activity, RNA polymerase II transcription factor binding)
GO:0001223 (transcription coactivator binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0008144 (drug binding)
GO:0008270 (zinc ion binding)
GO:0008289 (lipid binding)
GO:0019902 (phosphatase binding)
GO:0019904 (protein domain specific binding)
GO:0031624 (ubiquitin conjugating enzyme binding)
GO:0038023 (signaling receptor activity)
GO:0043565 (sequence-specific DNA binding)
GO:0044877 (macromolecular complex binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0051525 (NFAT protein binding)
GO:0097371 (MDM2/MDM4 family protein binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001666 (response to hypoxia)
GO:0006006 (glucose metabolic process)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0007507 (heart development)
GO:0007623 (circadian rhythm)
GO:0008544 (epidermis development)
GO:0010468 (regulation of gene expression)
GO:0010745 (negative regulation of macrophage derived foam cell differentiation)
GO:0010871 (negative regulation of receptor biosynthetic process)
GO:0010887 (negative regulation of cholesterol storage)
GO:0010891 (negative regulation of sequestering of triglyceride)
GO:0019217 (regulation of fatty acid metabolic process)
GO:0030522 (intracellular receptor signaling pathway)
GO:0032091 (negative regulation of protein binding)
GO:0032099 (negative regulation of appetite)
GO:0032868 (response to insulin)
GO:0032922 (circadian regulation of gene expression)
GO:0035095 (behavioral response to nicotine)
GO:0042060 (wound healing)
GO:0042157 (lipoprotein metabolic process)
GO:0042752 (regulation of circadian rhythm)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045722 (positive regulation of gluconeogenesis)
GO:0045776 (negative regulation of blood pressure)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046321 (positive regulation of fatty acid oxidation)
GO:0048511 (rhythmic process)
GO:0050728 (negative regulation of inflammatory response)
GO:0070166 (enamel mineralization)
GO:0072363 (regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter)
GO:0072366 (regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter)
GO:0072369 (regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter)
GO:1901215 (negative regulation of neuron death)
GO:1902894 (negative regulation of pri-miRNA transcription from RNA polymerase II promoter)
GO:1903038 (negative regulation of leukocyte cell-cell adhesion)
GO:2000678 (negative regulation of transcription regulatory region DNA binding)

Target Cross References - Protein

canSAR P23204
IntAct P23204
Guide to Pharmacology 593
Reactome R-MMU-1368110 (Bmal1:Clock,Npas2 activates circadian gene expression.)
R-MMU-383280 (Nuclear Receptor transcription pathway.)
R-MMU-400206 (Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).)
UniProt P23204

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR003074 (1Cnucl_rcpt.)
IPR003076 (PPAR-alpha.)
IPR013088 (Znf_NHR/GATA.)
IPR035500 (NHR_like_dom_sf.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)
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