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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2123
Target Type SINGLE PROTEIN
Preferred Name Pyrimidinergic receptor P2Y4
Synonyms NRU | P2P | P2RY4 | P2Y purinoceptor 4 | P2Y4 | UNR | Uridine nucleotide receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > nucleotide-like receptor (family a gpcr) > purine receptor

Target Components

Component Description Relationship Accession
P2Y purinoceptor 4 SINGLE PROTEIN P51582

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000186912
Ensembl ENSG00000186912
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005524 (ATP binding)
GO:0015065 (uridine nucleotide receptor activity)
GO:0045028 (G-protein coupled purinergic nucleotide receptor activity)
GO:0045030 (UTP-activated nucleotide receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0030321 (transepithelial chloride transport)
GO:0035589 (G-protein coupled purinergic nucleotide receptor signaling pathway)
GO:0071380 (cellular response to prostaglandin E stimulus)
Wikipedia P2RY4

Target Cross References - Protein

canSAR P51582
Human Protein Atlas ENSG00000186912
IntAct P51582
Guide to Pharmacology 325
Open Targets ENSG00000186912
PharmGKB PA32871
Pharos P51582 (Tchem)
Reactome R-HSA-417957 (P2Y receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt P51582 Q4VBB7 Q4VBB8 Q502W2 Q5JT22

Target Cross References - Domain

InterPro IPR000018 (P2Y4.)
IPR000276 (GPCR_Rhodpsn.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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