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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2111463
Target Type PROTEIN COMPLEX
Preferred Name GABA-B receptor
Synonyms G-protein coupled receptor 51 | GABA-B receptor 1 | GABA-B receptor 2 | GABA-B-R1 | GABA-B-R2 | GABA-BR1 | GABA-BR2 | GABABR1 | GABABR2 | GABBR1 | GABBR2 | GPR51 | GPRC3A | GPRC3B | Gamma-aminobutyric acid type B receptor subunit 1 | Gamma-aminobutyric acid type B receptor subunit 2 | Gb1 | Gb2 | HG20
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family c g protein-coupled receptor > small molecule receptor (family c gpcr) > neurotransmitter receptor (family c gpcr) > gaba-b receptor

Target Components

Component Description Relationship Accession
Gamma-aminobutyric acid type B receptor subunit 1 PROTEIN SUBUNIT Q9UBS5
Gamma-aminobutyric acid type B receptor subunit 2 PROTEIN SUBUNIT O75899

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2064 GABA-B receptor 1 SINGLE PROTEIN
CHEMBL5034 GABA-B receptor 2 SINGLE PROTEIN

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL701 BACLOFEN GABA-B receptor agonist 4 PubMed
CHEMBL1200682 SODIUM OXYBATE GABA-B receptor agonist 4 DailyMed PubMed
CHEMBL301742 ARBACLOFEN GABA-B receptor agonist 3 PubMed
CHEMBL2107312 ARBACLOFEN PLACARBIL GABA-B receptor agonist 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

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