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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2111369
Target Type PROTEIN FAMILY
Preferred Name Inosine-5'-monophosphate dehydrogenase (IMPDH)
Synonyms IMP dehydrogenase 1 | IMP dehydrogenase 2 | IMPD 1 | IMPD 2 | IMPD1 | IMPD2 | IMPDH 1 | IMPDH 2 | IMPDH-I | IMPDH-II | IMPDH1 | IMPDH2 | Inosine-5'-monophosphate dehydrogenase 1 | Inosine-5'-monophosphate dehydrogenase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Inosine-5'-monophosphate dehydrogenase 2 GROUP MEMBER P12268
Inosine-5'-monophosphate dehydrogenase 1 GROUP MEMBER P20839

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL1822 Inosine-5'-monophosphate dehydrogenase 1 SINGLE PROTEIN
CHEMBL2002 Inosine-5'-monophosphate dehydrogenase 2 SINGLE PROTEIN

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL727 THIOGUANINE Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor 4 DailyMed FDA
CHEMBL866 MYCOPHENOLIC ACID Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor 4 DailyMed
CHEMBL1456 MYCOPHENOLATE MOFETIL Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor 4 DailyMed PubMed PubMed PubMed
CHEMBL1200955 MYCOPHENOLATE MOFETIL HYDROCHLORIDE Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor 4 DailyMed PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

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