ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2111353
Target Type PROTEIN FAMILY
Preferred Name Serine/threonine-protein kinase AKT
Synonyms AKT1 | AKT2 | AKT3 | PKB alpha | PKB beta | PKB gamma | PKB | PKB | PKBG | Protein kinase Akt-2 | Protein kinase Akt-3 | Protein kinase B alpha | Protein kinase B beta | Protein kinase B gamma | Protein kinase B | Proto-oncogene c-Akt | RAC | RAC-PK-alpha | RAC-PK-beta | RAC-PK-gamma | RAC-alpha serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase | RAC-gamma serine/threonine-protein kinase | STK-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase akt family

Target Components

Component Description Relationship Accession
RAC-beta serine/threonine-protein kinase GROUP MEMBER P31751
RAC-gamma serine/threonine-protein kinase GROUP MEMBER Q9Y243
RAC-alpha serine/threonine-protein kinase GROUP MEMBER P31749

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038463 AKT/p21CIP1 PROTEIN COMPLEX
CHEMBL3885629 RAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1 PROTEIN FAMILY
CHEMBL2431 Serine/threonine-protein kinase AKT2 SINGLE PROTEIN
CHEMBL4816 Serine/threonine-protein kinase AKT3 SINGLE PROTEIN
CHEMBL4282 Serine/threonine-protein kinase AKT SINGLE PROTEIN

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2177390 IPATASERTIB Serine/threonine-protein kinase AKT inhibitor 3 PubMed PubMed
CHEMBL462018 TRICIRIBINE PHOSPHATE Serine/threonine-protein kinase AKT inhibitor 2 PubMed PubMed
CHEMBL1079175 MK-2206 Serine/threonine-protein kinase AKT inhibitor 2 Other PubMed
CHEMBL2178577 AZD-5363 Serine/threonine-protein kinase AKT inhibitor 2 PubMed
CHEMBL2219422 AFURESERTIB Serine/threonine-protein kinase AKT inhibitor 2 PubMed
CHEMBL3137336 UPROSERTIB Serine/threonine-protein kinase AKT inhibitor 2 PubMed
CHEMBL494089 GSK-690693 Serine/threonine-protein kinase AKT inhibitor 1 PubMed
CHEMBL3544935 XL-418 Serine/threonine-protein kinase AKT inhibitor 1 ClinicalTrials PubMed
CHEMBL3545000 MK-2201 Serine/threonine-protein kinase AKT inhibitor 1
CHEMBL3545134 LY-2780301 Serine/threonine-protein kinase AKT inhibitor 1 Other PubMed
CHEMBL3545422 ARQ-092 Serine/threonine-protein kinase AKT inhibitor 1 Other PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

spacer
spacer