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Target Report Card

Target Name and Classification

Target ID CHEMBL2111329
Preferred Name Adenosine receptor
Synonyms ADORA1 | ADORA2 | ADORA2A | ADORA2B | ADORA3 | Adenosine receptor A1 | Adenosine receptor A2a | Adenosine receptor A2b | Adenosine receptor A3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > nucleotide-like receptor (family a gpcr) > adenosine receptor

Target Components

Component Description Relationship Accession
Adenosine receptor A1 GROUP MEMBER P30542
Adenosine receptor A2a GROUP MEMBER P29274
Adenosine receptor A2b GROUP MEMBER P29275
Adenosine receptor A3 GROUP MEMBER P0DMS8

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885512 Adenosine receptor A1/Alpha-2A adrenergic receptor PROTEIN COMPLEX
CHEMBL2096679 Adenosine receptors; A1 & A2 SELECTIVITY GROUP
CHEMBL2095234 Adenosine receptors; A2b & A3 SELECTIVITY GROUP
CHEMBL2095195 Adenosine receptors; A1 & A3 SELECTIVITY GROUP
CHEMBL2096908 Adenosine receptors; A1 & A2b SELECTIVITY GROUP
CHEMBL226 Adenosine A1 receptor SINGLE PROTEIN
CHEMBL255 Adenosine A2b receptor SINGLE PROTEIN
CHEMBL2095213 Adenosine receptors; A2a & A3 SELECTIVITY GROUP
CHEMBL256 Adenosine A3 receptor SINGLE PROTEIN
CHEMBL2094257 Adenosine A2 receptor PROTEIN FAMILY
CHEMBL251 Adenosine A2a receptor SINGLE PROTEIN
CHEMBL2096982 Adenosine receptors; A1 & A2a SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL477 ADENOSINE Adenosine receptor agonist 4 FDA ISBN
CHEMBL113 CAFFEINE Adenosine receptor antagonist 4 FDA PubMed
CHEMBL190 THEOPHYLLINE Adenosine receptor antagonist 4 PubMed PubMed PubMed PubMed
CHEMBL1200434 OXTRIPHYLLINE Adenosine receptor antagonist 4 PubMed PubMed PubMed PubMed
CHEMBL1200569 CAFFEINE, CITRATED Adenosine receptor antagonist 4 FDA PubMed
CHEMBL1200578 THEOPHYLLINE SODIUM GLYCINATE Adenosine receptor antagonist 4 PubMed PubMed PubMed PubMed
CHEMBL1370561 AMINOPHYLLINE Adenosine receptor antagonist 4 PubMed PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties