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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2096972
Target Type PROTEIN COMPLEX
Preferred Name Sulfonylurea receptor 1, Kir6.2
Synonyms ABCC8 | ATP-binding cassette sub-family C member 8 | ATP-sensitive inward rectifier potassium channel 11 | HRINS | IKATP | Inward rectifier K(+) channel Kir6.2 | KCNJ11 | Potassium channel, inwardly rectifying subfamily J member 11 | SUR | SUR1 | Sulfonylurea receptor 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > potassium channels > inwardly rectifying potassium channel
  • transporter > primary active transporter > atp-binding cassette > abcc subfamily

Target Components

Component Description Relationship Accession
ATP-sensitive inward rectifier potassium channel 11 PROTEIN SUBUNIT Q14654
ATP-binding cassette sub-family C member 8 PROTEIN SUBUNIT Q09428

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095152 Sulfonylurea receptors; K-ATP channels PROTEIN COMPLEX GROUP
CHEMBL2071 Sulfonylurea receptor 1 SINGLE PROTEIN
CHEMBL1886 Potassium channel, inwardly rectifying, subfamily J, member 11 SINGLE PROTEIN
CHEMBL2095198 Sulfonylurea receptor 2, Kir6.2 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL472 GLYBURIDE Sulfonylurea receptor 1, Kir6.2 blocker 4 FDA
CHEMBL498 CHLORPROPAMIDE Sulfonylurea receptor 1, Kir6.2 blocker 4 FDA PubMed PubMed
CHEMBL782 TOLBUTAMIDE Sulfonylurea receptor 1, Kir6.2 blocker 4 PubMed PubMed PubMed PubMed
CHEMBL783 NATEGLINIDE Sulfonylurea receptor 1, Kir6.2 blocker 4 PubMed PubMed PubMed PubMed
CHEMBL817 TOLAZAMIDE Sulfonylurea receptor 1, Kir6.2 blocker 4 PubMed PubMed
CHEMBL1073 GLIPIZIDE Sulfonylurea receptor 1, Kir6.2 blocker 4 DailyMed PubMed
CHEMBL1272 REPAGLINIDE Sulfonylurea receptor 1, Kir6.2 blocker 4 PubMed PubMed PubMed PubMed
CHEMBL1481 GLIMEPIRIDE Sulfonylurea receptor 1, Kir6.2 blocker 4 DailyMed PubMed PubMed PubMed
CHEMBL1589 ACETOHEXAMIDE Sulfonylurea receptor 1, Kir6.2 blocker 4 PubMed PubMed
CHEMBL1200874 TOLBUTAMIDE SODIUM, STERILE Sulfonylurea receptor 1, Kir6.2 blocker 4 PubMed PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

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