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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2095229
Target Type PROTEIN FAMILY
Preferred Name Voltage-gated L-type calcium channel
Synonyms CACH1 | CACH2 | CACH3 | CACN1 | CACN2 | CACN4 | CACNA1C | CACNA1D | CACNA1F | CACNA1S | CACNAF1 | CACNL1A1 | CACNL1A2 | CACNL1A3 | CCHL1A1 | CCHL1A2 | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | Calcium channel, L type, alpha-1 polypeptide, isoform 2 | Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle | Voltage-dependent L-type calcium channel subunit alpha-1C | Voltage-dependent L-type calcium channel subunit alpha-1D | Voltage-dependent L-type calcium channel subunit alpha-1F | Voltage-dependent L-type calcium channel subunit alpha-1S | Voltage-gated calcium channel subunit alpha Cav1.1 | Voltage-gated calcium channel subunit alpha Cav1.2 | Voltage-gated calcium channel subunit alpha Cav1.3 | Voltage-gated calcium channel subunit alpha Cav1.4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated calcium channel

Target Components

Component Description Relationship Accession
Voltage-dependent L-type calcium channel subunit alpha-1D GROUP MEMBER Q01668
Voltage-dependent L-type calcium channel subunit alpha-1C GROUP MEMBER Q13936
Voltage-dependent L-type calcium channel subunit alpha-1S GROUP MEMBER Q13698
Voltage-dependent L-type calcium channel subunit alpha-1F GROUP MEMBER O60840

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3805 Voltage-gated L-type calcium channel alpha-1S subunit SINGLE PROTEIN
CHEMBL4138 Voltage-gated L-type calcium channel alpha-1D subunit SINGLE PROTEIN
CHEMBL2363032 Voltage-gated calcium channel PROTEIN COMPLEX GROUP
CHEMBL1940 Voltage-gated L-type calcium channel alpha-1C subunit SINGLE PROTEIN

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1280 VERAPAMIL HYDROCHLORIDE Voltage-gated L-type calcium channel blocker 4 FDA ISBN
CHEMBL1428 NIMODIPINE Voltage-gated L-type calcium channel blocker 4 DailyMed
CHEMBL1480 FELODIPINE Voltage-gated L-type calcium channel blocker 4 DailyMed
CHEMBL193 NIFEDIPINE Voltage-gated L-type calcium channel blocker 4 DailyMed FDA
CHEMBL1648 ISRADIPINE Voltage-gated L-type calcium channel blocker 4 DailyMed DailyMed
CHEMBL1697 DILTIAZEM HYDROCHLORIDE Voltage-gated L-type calcium channel blocker 4 DailyMed
CHEMBL1726 NISOLDIPINE Voltage-gated L-type calcium channel blocker 4 DailyMed
CHEMBL1200326 NICARDIPINE HYDROCHLORIDE Voltage-gated L-type calcium channel blocker 4 FDA PubMed PubMed
CHEMBL1200402 AMLODIPINE BESYLATE Voltage-gated L-type calcium channel blocker 4 DailyMed
CHEMBL1200805 DILTIAZEM MALATE Voltage-gated L-type calcium channel blocker 4 DailyMed
CHEMBL1200984 AMLODIPINE MALEATE Voltage-gated L-type calcium channel blocker 4 DailyMed
CHEMBL1201729 DRONEDARONE HYDROCHLORIDE Voltage-gated L-type calcium channel blocker 4 Expert FDA PubMed
CHEMBL1237132 CLEVIDIPINE Voltage-gated L-type calcium channel blocker 4 DailyMed
CHEMBL3545169 AZD1305 Voltage-gated L-type calcium channel blocker 2 PubMed PubMed
CHEMBL29919 ELPETRIGINE Voltage-gated L-type calcium channel blocker 0 PubMed PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

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