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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2095227
Target Type PROTEIN FAMILY
Preferred Name Vascular endothelial growth factor receptor
Synonyms CD_antigen=CD309 | FLK-1 | FLK1 | FLT | FLT | FLT-1 | FLT-4 | FLT1 | FLT4 | FRT | Fetal liver kinase 1 | Fms-like tyrosine kinase 1 | Fms-like tyrosine kinase 4 | KDR | KDR | Kinase insert domain receptor | Protein-tyrosine kinase receptor flk-1 | Tyrosine-protein kinase FRT | Tyrosine-protein kinase receptor FLT | Tyrosine-protein kinase receptor FLT4 | VEGFR-1 | VEGFR-2 | VEGFR-3 | VEGFR1 | VEGFR2 | VEGFR3 | Vascular endothelial growth factor receptor 1 | Vascular endothelial growth factor receptor 2 | Vascular endothelial growth factor receptor 3 | Vascular permeability factor receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase vegfr family

Target Components

Component Description Relationship Accession
Vascular endothelial growth factor receptor 2 GROUP MEMBER P35968
Vascular endothelial growth factor receptor 1 GROUP MEMBER P17948
Vascular endothelial growth factor receptor 3 GROUP MEMBER P35916

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL1868 Vascular endothelial growth factor receptor 1 SINGLE PROTEIN
CHEMBL279 Vascular endothelial growth factor receptor 2 SINGLE PROTEIN
CHEMBL1955 Vascular endothelial growth factor receptor 3 SINGLE PROTEIN
CHEMBL2111375 Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2) SELECTIVITY GROUP
CHEMBL2111336 VEGF-receptor 2 and tyrosine-protein kinase SRC SELECTIVITY GROUP
CHEMBL2111428 VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT) SELECTIVITY GROUP
CHEMBL3301389 Focal adhesion kinase 1/vascular endothelial growth factor receptor 3 PROTEIN-PROTEIN INTERACTION
CHEMBL2111409 Vascular endothelial growth factor receptor 2 and 3 (KDR and Flt-4) SELECTIVITY GROUP
CHEMBL2111480 Vascular endothelial growth factor receptor 1 and 2 (Flt-1 and KDR) SELECTIVITY GROUP
CHEMBL2111434 VEGF-receptor 2 and Fibroblast growth factor receptor 2 SELECTIVITY GROUP
CHEMBL2111439 VEGF-receptor 2 and Fibroblast growth factor receptor 1 PROTEIN FAMILY
CHEMBL2111440 VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta) SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL24828 VANDETANIB Vascular endothelial growth factor receptor inhibitor 4 DailyMed
CHEMBL1567 SUNITINIB MALATE Vascular endothelial growth factor receptor inhibitor 4 DailyMed
CHEMBL1200485 SORAFENIB TOSYLATE Vascular endothelial growth factor receptor inhibitor 4 FDA
CHEMBL1201733 PAZOPANIB HYDROCHLORIDE Vascular endothelial growth factor receptor inhibitor 4 DailyMed
CHEMBL1289494 TIVOZANIB Vascular endothelial growth factor receptor inhibitor 4 PubMed PubMed
CHEMBL1289926 AXITINIB Vascular endothelial growth factor receptor inhibitor 4 DailyMed
CHEMBL1946170 REGORAFENIB Vascular endothelial growth factor receptor inhibitor 4 Expert
CHEMBL2105704 LENVATINIB MESYLATE Vascular endothelial growth factor receptor inhibitor 4 DailyMed
CHEMBL3039504 NINTEDANIB ESYLATE Vascular endothelial growth factor receptor inhibitor 4 FDA
CHEMBL276711 SEMAXANIB Vascular endothelial growth factor receptor inhibitor 3 PubMed PubMed
CHEMBL101253 VATALANIB Vascular endothelial growth factor receptor inhibitor 3 PubMed PubMed
CHEMBL377300 BRIVANIB Vascular endothelial growth factor receptor inhibitor 3 PubMed PubMed
CHEMBL223360 LINIFANIB Vascular endothelial growth factor receptor inhibitor 3 PubMed PubMed
CHEMBL270995 BRIVANIB ALANINATE Vascular endothelial growth factor receptor inhibitor 3 PubMed PubMed
CHEMBL491473 CEDIRANIB Vascular endothelial growth factor receptor inhibitor 3 PubMed
CHEMBL522892 DOVITINIB Vascular endothelial growth factor receptor inhibitor 3 PubMed
CHEMBL572881 MOTESANIB Vascular endothelial growth factor receptor inhibitor 3 PubMed
CHEMBL3545251 SULFATINIB Vascular endothelial growth factor receptor inhibitor 3 ClinicalTrials Other Other
CHEMBL3545339 FRUQUINTINIB Vascular endothelial growth factor receptor inhibitor 3 PubMed
CHEMBL254760 MGCD-265 Vascular endothelial growth factor receptor inhibitor 2 Other PubMed
CHEMBL1230609 FORETINIB Vascular endothelial growth factor receptor inhibitor 2 Other PubMed
CHEMBL1721885 SU-014813 Vascular endothelial growth factor receptor inhibitor 2 PubMed
CHEMBL1980297 ILORASERTIB Vascular endothelial growth factor receptor inhibitor 2 PubMed
CHEMBL2220486 LUCITANIB Vascular endothelial growth factor receptor inhibitor 2 Other PubMed PubMed
CHEMBL3545160 SU-14813 Vascular endothelial growth factor receptor inhibitor 2 PubMed
CHEMBL3545285 XL-999 Vascular endothelial growth factor receptor inhibitor 2 DOI Other PubMed
CHEMBL3545335 AG-13958 Vascular endothelial growth factor receptor inhibitor 2 Other
CHEMBL3545396 BMS-690514 Vascular endothelial growth factor receptor inhibitor 2 PubMed PubMed
CHEMBL3545401 X-82 Vascular endothelial growth factor receptor inhibitor 2 Other Other
CHEMBL3545402 XL-820 Vascular endothelial growth factor receptor inhibitor 2 Other Other
CHEMBL346631 CEP-7055 Vascular endothelial growth factor receptor inhibitor 1 PubMed PubMed
CHEMBL150894 CEP-5214 Vascular endothelial growth factor receptor inhibitor 1 PubMed
CHEMBL406381 KRN-633 Vascular endothelial growth factor receptor inhibitor 1 PubMed
CHEMBL1614710 OSI-930 Vascular endothelial growth factor receptor inhibitor 1 PubMed PubMed
CHEMBL1980391 RG-1530 Vascular endothelial growth factor receptor inhibitor 1 PubMed PubMed
CHEMBL2010872 CEP-11981 Vascular endothelial growth factor receptor inhibitor 1 PubMed
CHEMBL2180604 TAK-593 Vascular endothelial growth factor receptor inhibitor 1 PubMed
CHEMBL3544927 L-21649 Vascular endothelial growth factor receptor inhibitor 1 Other
CHEMBL3545300 CP-459632 Vascular endothelial growth factor receptor inhibitor 1
CHEMBL3545358 4SC-203 Vascular endothelial growth factor receptor inhibitor 1 Other Other
CHEMBL3545428 CHIAURANIB Vascular endothelial growth factor receptor inhibitor 1 Other
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

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