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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2093869
Target Type PROTEIN COMPLEX
Preferred Name Integrin alpha-IIb/beta-3
Synonyms CD_antigen=CD41 | CD_antigen=CD61 | GP2B | GP3A | GPIIIa | GPIIb | GPalpha IIb | ITGA2B | ITGAB | ITGB3 | Integrin alpha-IIb heavy chain | Integrin alpha-IIb light chain, form 1 | Integrin alpha-IIb light chain, form 2 | Integrin alpha-IIb | Integrin beta-3 | Platelet membrane glycoprotein IIIa | Platelet membrane glycoprotein IIb
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Integrin beta-3 PROTEIN SUBUNIT P05106
Integrin alpha-IIb PROTEIN SUBUNIT P08514

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111443 Integrin alpha-V/beta-3 and alpha-IIb/beta 3 SELECTIVITY GROUP
CHEMBL212 Integrin alpha-IIb SINGLE PROTEIN
CHEMBL1907598 Integrin alpha-V/beta-3 PROTEIN COMPLEX
CHEMBL2111461 Integrin alpha-2/beta-3 PROTEIN COMPLEX
CHEMBL2111425 Fibronectin receptor (Integrin alpha-5/beta-1 and alpha-V/beta-3) PROTEIN COMPLEX GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1174 EPTIFIBATIDE Integrin alpha-IIb/beta-3 inhibitor 4 DailyMed
CHEMBL1704 TIROFIBAN HYDROCHLORIDE Integrin alpha-IIb/beta-3 inhibitor 4 DailyMed
CHEMBL1201584 ABCIXIMAB Integrin alpha-IIb/beta-3 inhibitor 4 DailyMed
CHEMBL1743076 TADOCIZUMAB Integrin alpha-IIb/beta-3 antagonist 2 PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Protein

Complex Portal EBI-2554508
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