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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL209
Target Type SINGLE PROTEIN
Preferred Name Trypsin I
Synonyms Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRYP1 | Trypsin I | Trypsin-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Trypsin-1 SINGLE PROTEIN P07477

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095204 Trypsin PROTEIN FAMILY
CHEMBL2096988 Thrombin & trypsin SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000204983 ENSG00000274247
Ensembl ENSG00000204983 ENSG00000274247
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0070062 (extracellular exosome)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0007586 (digestion)
GO:0009235 (cobalamin metabolic process)
GO:0022617 (extracellular matrix disassembly)
Wikipedia Trypsin_1

Target Cross References - Protein

canSAR P07477
CGD Pancreatitis, hereditary
Human Protein Atlas ENSG00000204983 ENSG00000274247
IntAct P07477
Guide to Pharmacology 2397
Open Targets ENSG00000204983 ENSG00000274247
PharmGKB PA33828
Reactome R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
R-HSA-196741 (Cobalamin (Cbl, vitamin B12) transport and metabolism.)
UniProt A1A509 A6NJ71 B2R5I5 P07477 Q5NV57 Q7M4N3 Q7M4N4 Q92955 Q9HAN4 Q9HAN5 Q9HAN6 Q9HAN7

Target Cross References - Domain

InterPro IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR009003 (Peptidase_S1_PA.)
IPR018114 (TRYPSIN_HIS.)
IPR033116 (TRYPSIN_SER.)
Pfam PF00089 (Trypsin)

Target Cross References - Structure

PDBe 1FXY 1TRN 2RA3 4WWY 4WXV
CREDO 1FXY 1TRN 2RA3 4WWY 4WXV
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