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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2079849
Preferred Name Serine protease hepsin
Synonyms HPN | Serine protease hepsin catalytic chain | Serine protease hepsin non-catalytic chain | Serine protease hepsin | TMPRSS1 | Transmembrane protease serine 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease

Target Components

Component Description Relationship Accession
Serine protease hepsin SINGLE PROTEIN P05981

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885586 Hepatocyte growth factor activator/Serine protease hepsin/Suppressor of tumorigenicity 14 protein PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105707
Ensembl ENSG00000105707
GO Cellular Component GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005911 (cell-cell junction)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0031965 (nuclear membrane)
GO:0043025 (neuronal cell body)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0015269 (calcium-activated potassium channel activity)
GO:0016787 (hydrolase activity)
GO:0070008 (serine-type exopeptidase activity)
GO Biological Process GO:0006508 (proteolysis)
GO:0008360 (regulation of cell shape)
GO:0010628 (positive regulation of gene expression)
GO:0010719 (negative regulation of epithelial to mesenchymal transition)
GO:0010756 (positive regulation of plasminogen activation)
GO:0030307 (positive regulation of cell growth)
GO:0034769 (basement membrane disassembly)
GO:0043066 (negative regulation of apoptotic process)
GO:0043923 (positive regulation by host of viral transcription)
GO:0048012 (hepatocyte growth factor receptor signaling pathway)
GO:0050680 (negative regulation of epithelial cell proliferation)
GO:0050910 (detection of mechanical stimulus involved in sensory perception of sound)
GO:0071805 (potassium ion transmembrane transport)
GO:0090103 (cochlea morphogenesis)
GO:0097066 (response to thyroid hormone)
GO:0097195 (pilomotor reflex)
GO:2000347 (positive regulation of hepatocyte proliferation)
GO:2000611 (positive regulation of thyroid hormone generation)

Target Cross References - Protein

Human Protein Atlas ENSG00000105707
IntAct P05981
Open Targets ENSG00000105707
PharmGKB PA29425
Reactome R-HSA-6806942 (MET Receptor Activation.)
R-HSA-8852405 (Signaling by MST1.)
UniProt B2RDS4 P05981

Target Cross References - Domain

InterPro IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR009003 (Peptidase_S1_PA.)
IPR015352 (Hepsin-SRCR_dom.)
IPR017448 (SRCR-like_dom.)
IPR036772 (SRCR-like_dom_sf.)
Pfam PF00089 (Trypsin)
PF09272 (Hepsin-SRCR)

Target Cross References - Structure

PDBe 1O5E 1O5F 1P57 1Z8G 3T2N 5CE1
CREDO 1O5E 1O5F 1P57 1Z8G 3T2N 5CE1