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Target Report Card

Target Name and Classification

Target ID CHEMBL2069
Preferred Name Thromboxane A2 receptor
Synonyms Prostanoid TP receptor | TBXA2R | TXA2-R | Thromboxane A2 receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > prostanoid receptor

Target Components

Component Description Relationship Accession
Thromboxane A2 receptor SINGLE PROTEIN P21731

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2107786 TERUTROBAN Thromboxane A2 receptor antagonist 3 PubMed
CHEMBL281398 TERBOGREL Thromboxane A2 receptor antagonist 2 PubMed PubMed PubMed PubMed
CHEMBL70972 SERATRODAST Thromboxane A2 receptor antagonist 0 PubMed PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000006638
Ensembl ENSG00000006638
GO Cellular Component GO:0001669 (acrosomal vesicle)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016607 (nuclear speck)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004960 (thromboxane receptor activity)
GO:0004961 (thromboxane A2 receptor activity)
GO:0005085 (guanyl-nucleotide exchange factor activity)
GO:0005515 (protein binding)
GO Biological Process GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007584 (response to nutrient)
GO:0019229 (regulation of vasoconstriction)
GO:0019932 (second-messenger-mediated signaling)
GO:0030194 (positive regulation of blood coagulation)
GO:0032496 (response to lipopolysaccharide)
GO:0033574 (response to testosterone)
GO:0038193 (thromboxane A2 signaling pathway)
GO:0042493 (response to drug)
GO:0045471 (response to ethanol)
GO:0045766 (positive regulation of angiogenesis)
GO:0045777 (positive regulation of blood pressure)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0090051 (negative regulation of cell migration involved in sprouting angiogenesis)
Wikipedia Thromboxane_receptor

Target Cross References - Protein

canSAR P21731
CGD Bleeding disorder, platelet-type 13, susceptibility to
Human Protein Atlas ENSG00000006638
IntAct P21731
Guide to Pharmacology 346
Open Targets ENSG00000006638
PharmGKB PA348
Pharos P21731 (Tclin)
Reactome R-HSA-391908 (Prostanoid ligand receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-416482 (G alpha (12/13) signalling events.)
R-HSA-428930 (Thromboxane signalling through TP receptor.)
UniProt O75228 P21731 Q6DK52 Q9UCY1 Q9UCY2

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001105 (Thbox_rcpt.)
IPR008365 (Prostanoid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)