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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2027
Target Type SINGLE PROTEIN
Preferred Name Niemann-Pick C1-like protein 1
Synonyms NPC1-like intracellular cholesterol transporter 1 | NPC1L1 | Niemann-Pick C1-like protein 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other membrane protein

Target Components

Component Description Relationship Accession
NPC1-like intracellular cholesterol transporter 1 SINGLE PROTEIN Q9UHC9

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1138 EZETIMIBE Niemann-Pick C1-like protein 1 inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000015520
Ensembl ENSG00000015520
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0030659 (cytoplasmic vesicle membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0031526 (brush border membrane)
GO:0044214 (spanning component of plasma membrane)
GO Molecular Function GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0017137 (Rab GTPase binding)
GO:0031489 (myosin V binding)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006695 (cholesterol biosynthetic process)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0030299 (intestinal cholesterol absorption)
GO:0030301 (cholesterol transport)
GO:0042157 (lipoprotein metabolic process)
GO:0042493 (response to drug)
GO:0071501 (cellular response to sterol depletion)
GO:0098856 (intestinal lipid absorption)

Target Cross References - Protein

canSAR Q9UHC9
CGD Ezetimibe, nonresponse to
Human Protein Atlas ENSG00000015520
IntAct Q9UHC9
Guide to Pharmacology 2629
Open Targets ENSG00000015520
PharmGKB PA31699
Reactome R-HSA-8963678 (Intestinal lipid absorption.)
UniProt A4D2J7 B7ZLE6 D3DVK9 Q17RV5 Q6R3Q4 Q9UHC8 Q9UHC9

Target Cross References - Domain

InterPro IPR000731 (SSD.)
IPR003392 (Ptc/Disp.)
IPR032190 (NPC1_N.)
Pfam PF02460 (Patched)
PF12349 (Sterol-sensing)
PF16414 (NPC1_N)

Target Cross References - Structure

PDBe 3QNT
CREDO 3QNT
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