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Target Report Card

Target Name and Classification

Target ID CHEMBL2014
Target Type SINGLE PROTEIN
Preferred Name Nociceptin receptor
Synonyms KOR-3 | Kappa-type 3 opioid receptor | Nociceptin receptor | OOR | OPRL1 | ORL1 | Orphanin FQ receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > opioid receptor

Target Components

Component Description Relationship Accession
Nociceptin receptor SINGLE PROTEIN P41146

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2364605 CEBRANOPADOL Nociceptin receptor agonist 3 PubMed PubMed
CHEMBL3545406 LY2940094 Nociceptin receptor antagonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000125510
Ensembl ENSG00000125510
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0043005 (neuron projection)
GO Molecular Function GO:0001626 (nociceptin receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004985 (opioid receptor activity)
GO:0005515 (protein binding)
GO:0008022 (protein C-terminus binding)
GO:0042923 (neuropeptide binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007218 (neuropeptide signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007600 (sensory perception)
GO:0007610 (behavior)
GO:0019233 (sensory perception of pain)
GO:0032355 (response to estradiol)
GO:0035810 (positive regulation of urine volume)
GO:0038003 (opioid receptor signaling pathway)
GO:0042755 (eating behavior)
GO:0043951 (negative regulation of cAMP-mediated signaling)
GO:0044849 (estrous cycle)
GO:0045776 (negative regulation of blood pressure)
GO:0051930 (regulation of sensory perception of pain)
GO:0060454 (positive regulation of gastric acid secretion)
GO:0106072 (negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:1901386 (negative regulation of voltage-gated calcium channel activity)
GO:1904058 (positive regulation of sensory perception of pain)
GO:1904059 (regulation of locomotor rhythm)
Wikipedia Nociceptin_receptor

Target Cross References - Protein

canSAR P41146
Human Protein Atlas ENSG00000125510
IntAct P41146
Guide to Pharmacology 320
Open Targets ENSG00000125510
PharmGKB PA31944
Pharos P41146 (Tchem)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt P41146 Q8TD34 Q8WYH9 Q9H4K4

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001418 (Opioid_rcpt.)
IPR001420 (X_opioid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 4EA3 5DHG 5DHH
CREDO 4EA3 5DHG 5DHH
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