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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2007628
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein phosphatase non-receptor type 5
Synonyms Neural-specific protein-tyrosine phosphatase | PTPN5 | STEP | Striatum-enriched protein-tyrosine phosphatase | Tyrosine-protein phosphatase non-receptor type 5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > tyrosine protein phosphatase

Target Components

Component Description Relationship Accession
Tyrosine-protein phosphatase non-receptor type 5 SINGLE PROTEIN P54829

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000110786
Ensembl ENSG00000110786
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0001784 (phosphotyrosine binding)
GO:0004721 (phosphoprotein phosphatase activity)
GO:0004725 (protein tyrosine phosphatase activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO Biological Process GO:0006470 (protein dephosphorylation)
GO:0016311 (dephosphorylation)
GO:0035335 (peptidyl-tyrosine dephosphorylation)
GO:0071345 (cellular response to cytokine stimulus)

Target Cross References - Protein

Human Protein Atlas ENSG00000110786
IntAct P54829
Open Targets ENSG00000110786
PharmGKB PA34001
Reactome R-HSA-9008059 (Interleukin-37 signaling.)
UniProt B3KXG7 B7Z386 B7ZAF5 D3DQY7 P54829 Q6P1Z2 Q8N2A1 Q8NDP8

Target Cross References - Domain

InterPro IPR000242 (PTPase_domain.)
IPR000387 (TYR_PHOSPHATASE_dom.)
IPR003595 (Tyr_Pase_cat.)
IPR008356 (Tyr_Pase_KIM-con.)
IPR016130 (Tyr_Pase_AS.)
IPR016334 (Tyr_Pase_rcpt_R/non-rcpt_5.)
IPR029021 (Prot-tyrosine_phosphatase-like.)
Pfam PF00102 (Y_phosphatase)

Target Cross References - Structure

PDBe 2BIJ 2BV5 2CJZ 5OVR 5OVX 5OW1
CREDO 2BIJ 2BV5 2CJZ 5OVR 5OVX 5OW1
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