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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2002
Target Type SINGLE PROTEIN
Preferred Name Inosine-5'-monophosphate dehydrogenase 2
Synonyms IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH 2 | IMPDH-II | IMPDH2 | Inosine-5'-monophosphate dehydrogenase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Inosine-5'-monophosphate dehydrogenase 2 SINGLE PROTEIN P12268

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111369 Inosine-5'-monophosphate dehydrogenase (IMPDH) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000178035
Ensembl ENSG00000178035
GO Cellular Component GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005778 (peroxisomal membrane)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0034774 (secretory granule lumen)
GO:0070062 (extracellular exosome)
GO:1904813 (ficolin-1-rich granule lumen)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003677 (DNA binding)
GO:0003723 (RNA binding)
GO:0003824 (catalytic activity)
GO:0003938 (IMP dehydrogenase activity)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006164 (purine nucleotide biosynthetic process)
GO:0006177 (GMP biosynthetic process)
GO:0006183 (GTP biosynthetic process)
GO:0007623 (circadian rhythm)
GO:0009168 (purine ribonucleoside monophosphate biosynthetic process)
GO:0043312 (neutrophil degranulation)
GO:0046651 (lymphocyte proliferation)
GO:0051289 (protein homotetramerization)
GO:0055114 (oxidation-reduction process)
GO:0060041 (retina development in camera-type eye)
GO:0071353 (cellular response to interleukin-4)
Wikipedia IMPDH2

Target Cross References - Protein

canSAR P12268
CGD IMPDH2 enzyme activity, variation in
Human Protein Atlas ENSG00000178035
IntAct P12268
Guide to Pharmacology 2625
Open Targets ENSG00000178035
PharmGKB PA29863
Reactome R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-73817 (Purine ribonucleoside monophosphate biosynthesis.)
UniProt P12268 Q6LEF3

Target Cross References - Domain

InterPro IPR000644 (CBS_dom.)
IPR001093 (IMP_DH_GMPRt.)
IPR005990 (IMP_DH.)
IPR013785 (Aldolase_TIM.)
IPR015875 (IMP_DH/GMP_Rdtase_CS.)
Pfam PF00478 (IMPDH)
PF00571 (CBS)

Target Cross References - Structure

PDBe 1B3O 1NF7 1NFB
CREDO 1B3O 1NF7 1NFB
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