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Target Report Card

Target Name and Classification

Target ID CHEMBL2001
Preferred Name Purinergic receptor P2Y12
Synonyms ADP-glucose receptor | ADPG-R | HORK3 | P2RY12 | P2T(AC) | P2Y purinoceptor 12 | P2Y(AC) | P2Y(ADP) | P2Y(cyc) | P2Y12 platelet ADP receptor | P2Y12 | SP1999
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > nucleotide-like receptor (family a gpcr) > purine receptor

Target Components

Component Description Relationship Accession
P2Y purinoceptor 12 SINGLE PROTEIN Q9H244

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL398435 TICAGRELOR Purinergic receptor P2Y12 negative allosteric modulator 4 FDA
CHEMBL1717 TICLOPIDINE HYDROCHLORIDE Purinergic receptor P2Y12 antagonist 4 PubMed PubMed PubMed
CHEMBL1097279 CANGRELOR TETRASODIUM Purinergic receptor P2Y12 antagonist 4 FDA
CHEMBL1083385 CLOPIDOGREL BISULFATE Purinergic receptor P2Y12 antagonist 4 DailyMed
CHEMBL1201773 PRASUGREL HYDROCHLORIDE Purinergic receptor P2Y12 antagonist 4 DailyMed
CHEMBL261244 REGRELOR DISODIUM Purinergic receptor P2Y12 antagonist 2 PubMed
CHEMBL2103828 ELINOGREL Purinergic receptor P2Y12 antagonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000169313
Ensembl ENSG00000169313
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0009897 (external side of plasma membrane)
GO:0009925 (basal plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031224 (intrinsic component of membrane)
GO Molecular Function GO:0001609 (G-protein coupled adenosine receptor activity)
GO:0001621 (ADP receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005085 (guanyl-nucleotide exchange factor activity)
GO:0045028 (G-protein coupled purinergic nucleotide receptor activity)
GO Biological Process GO:0001973 (adenosine receptor signaling pathway)
GO:0006930 (substrate-dependent cell migration, cell extension)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007596 (blood coagulation)
GO:0007599 (hemostasis)
GO:0008347 (glial cell migration)
GO:0010700 (negative regulation of norepinephrine secretion)
GO:0030030 (cell projection organization)
GO:0030168 (platelet activation)
GO:0035589 (G-protein coupled purinergic nucleotide receptor signaling pathway)
GO:0043270 (positive regulation of ion transport)
GO:0043491 (protein kinase B signaling)
GO:0045596 (negative regulation of cell differentiation)
GO:0051924 (regulation of calcium ion transport)
GO:0070527 (platelet aggregation)
GO:0070588 (calcium ion transmembrane transport)
GO:0071318 (cellular response to ATP)
GO:0071407 (cellular response to organic cyclic compound)
GO:0071805 (potassium ion transmembrane transport)
GO:1904139 (regulation of microglial cell migration)
Wikipedia P2Y12

Target Cross References - Protein

canSAR Q9H244
CGD Bleeding disorder, platelet-type, 8
Human Protein Atlas ENSG00000169313
Guide to Pharmacology 328
Open Targets ENSG00000169313
PharmGKB PA134971947
Pharos Q9H244 (Tclin)
Reactome R-HSA-392170 (ADP signalling through P2Y purinoceptor 12.)
R-HSA-417957 (P2Y receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt D3DNJ5 Q546J7 Q9H244

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR005394 (P2Y12_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure