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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1987
Preferred Name Prostanoid FP receptor
Synonyms PGF receptor | PGF2-alpha receptor | PTGFR | Prostaglandin F2-alpha receptor | Prostanoid FP receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > prostanoid receptor

Target Components

Component Description Relationship Accession
Prostaglandin F2-alpha receptor SINGLE PROTEIN P43088

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1051 LATANOPROST Prostanoid FP receptor agonist 4 FDA
CHEMBL1200799 TRAVOPROST Prostanoid FP receptor agonist 4 DailyMed
CHEMBL1200896 DINOPROST TROMETHAMINE Prostanoid FP receptor agonist 4 ISBN
CHEMBL1200963 BIMATOPROST Prostanoid FP receptor agonist 4 KEGG PubMed PubMed PubMed PubMed
CHEMBL1237105 CARBOPROST TROMETHAMINE Prostanoid FP receptor agonist 4 KEGG PubMed
CHEMBL1963683 TAFLUPROST Prostanoid FP receptor agonist 4 FDA
CHEMBL2364612 LATANOPROSTENE BUNOD Prostanoid FP receptor agonist 4 Other PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000122420
Ensembl ENSG00000122420
GO Cellular Component GO:0005576 (extracellular region)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004958 (prostaglandin F receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007567 (parturition)
GO:0008284 (positive regulation of cell proliferation)
GO:0010628 (positive regulation of gene expression)
GO:0032355 (response to estradiol)
GO:0032496 (response to lipopolysaccharide)
GO:0035584 (calcium-mediated signaling using intracellular calcium source)
GO:0043066 (negative regulation of apoptotic process)
GO:0071799 (cellular response to prostaglandin D stimulus)
Wikipedia Prostaglandin_F_receptor

Target Cross References - Protein

canSAR P43088
Human Protein Atlas ENSG00000122420
Guide to Pharmacology 344
Open Targets ENSG00000122420
PharmGKB PA290
Pharos P43088 (Tclin)
Reactome R-HSA-391908 (Prostanoid ligand receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
UniProt A8K9Y0 P43088 Q2KHP3 Q6RYQ6 Q9P1X4

Target Cross References - Domain

InterPro IPR000141 (PglndnF_rcpt.)
IPR000276 (GPCR_Rhodpsn.)
IPR008365 (Prostanoid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)