ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1987
Target Type SINGLE PROTEIN
Preferred Name Prostanoid FP receptor
Synonyms PGF receptor | PGF2-alpha receptor | PTGFR | Prostaglandin F2-alpha receptor | Prostanoid FP receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > prostanoid receptor

Target Components

Component Description Relationship Accession
Prostaglandin F2-alpha receptor SINGLE PROTEIN P43088

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1051 LATANOPROST Prostanoid FP receptor agonist 4 FDA
CHEMBL1200799 TRAVOPROST Prostanoid FP receptor agonist 4 DailyMed
CHEMBL1200896 DINOPROST TROMETHAMINE Prostanoid FP receptor agonist 4 ISBN
CHEMBL1200963 BIMATOPROST Prostanoid FP receptor agonist 4 KEGG PubMed PubMed PubMed PubMed
CHEMBL1237105 CARBOPROST TROMETHAMINE Prostanoid FP receptor agonist 4 KEGG PubMed
CHEMBL1963683 TAFLUPROST Prostanoid FP receptor agonist 4 FDA
CHEMBL2364612 LATANOPROSTENE BUNOD Prostanoid FP receptor agonist 4 Other PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000122420
Ensembl ENSG00000122420
GO Cellular Component GO:0005576 (extracellular region)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004958 (prostaglandin F receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007567 (parturition)
GO:0008284 (positive regulation of cell proliferation)
GO:0010628 (positive regulation of gene expression)
GO:0032355 (response to estradiol)
GO:0032496 (response to lipopolysaccharide)
GO:0035584 (calcium-mediated signaling using intracellular calcium source)
GO:0043066 (negative regulation of apoptotic process)
GO:0071799 (cellular response to prostaglandin D stimulus)
Wikipedia Prostaglandin_F_receptor

Target Cross References - Protein

canSAR P43088
Human Protein Atlas ENSG00000122420
Guide to Pharmacology 344
Open Targets ENSG00000122420
PharmGKB PA290
Pharos P43088 (Tclin)
Reactome R-HSA-391908 (Prostanoid ligand receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
UniProt A8K9Y0 P43088 Q2KHP3 Q6RYQ6 Q9P1X4

Target Cross References - Domain

InterPro IPR000141 (PglndnF_rcpt.)
IPR000276 (GPCR_Rhodpsn.)
IPR008365 (Prostanoid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
spacer
spacer