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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1985
Preferred Name Glucagon receptor
Synonyms GCGR | GL-R | Glucagon receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family b g protein-coupled receptor > peptide receptor (family b gpcr) > glucagon-like receptor > glucagon receptor

Target Components

Component Description Relationship Accession
Glucagon receptor SINGLE PROTEIN P47871

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL266481 GLUCAGON Glucagon receptor agonist 4 PubMed
CHEMBL1201508 GLUCAGON HYDROCHLORIDE RECOMBINANT Glucagon receptor agonist 4 PubMed
CHEMBL1201618 GLUCAGON HYDROCHLORIDE Glucagon receptor agonist 4 PubMed
CHEMBL1933349 MK-0893 Glucagon receptor antagonist 2 PubMed PubMed
CHEMBL3544946 PF-06291874 Glucagon receptor antagonist 2 Other
CHEMBL3545269 SAR425899 Glucagon receptor agonist 2 Other
CHEMBL3707278 CROTEDUMAB Glucagon receptor inhibitor 1 Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000215644
Ensembl ENSG00000215644
GO Cellular Component GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004888 (transmembrane signaling receptor activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004967 (glucagon receptor activity)
GO:0005085 (guanyl-nucleotide exchange factor activity)
GO:0017046 (peptide hormone binding)
GO Biological Process GO:0006091 (generation of precursor metabolites and energy)
GO:0006887 (exocytosis)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007584 (response to nutrient)
GO:0008217 (regulation of blood pressure)
GO:0009755 (hormone-mediated signaling pathway)
GO:0042593 (glucose homeostasis)
GO:0042594 (response to starvation)
GO:0070873 (regulation of glycogen metabolic process)
GO:0071377 (cellular response to glucagon stimulus)
Wikipedia Glucagon_receptor

Target Cross References - Protein

canSAR P47871
Human Protein Atlas ENSG00000215644
IntAct P47871
Guide to Pharmacology 251
Open Targets ENSG00000215644
PharmGKB PA28607
Pharos P47871 (Tclin)
Reactome R-HSA-163359 (Glucagon signaling in metabolic regulation.)
R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-418555 (G alpha (s) signalling events.)
R-HSA-420092 (Glucagon-type ligand receptors.)
UniProt P47871 Q2M3M5

Target Cross References - Domain

InterPro IPR000832 (GPCR_2_secretin-like.)
IPR001879 (GPCR_2_extracellular_dom.)
IPR003290 (GPCR_2_GLP1/glucagon_rcpt.)
IPR003291 (GPCR_2_glucagon_rcpt.)
IPR017981 (GPCR_2-like.)
IPR017983 (GPCR_2_secretin-like_CS.)
IPR036445 (GPCR_2_extracell_dom_sf.)
Pfam PF00002 (7tm_2)
PF02793 (HRM)

Target Cross References - Structure

PDBe 2A83 3CZF 4ERS 4L6R 4LF3 5EE7 5XEZ