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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1977
Target Type SINGLE PROTEIN
Preferred Name Vitamin D receptor
Synonyms 1,25-dihydroxyvitamin D3 receptor | NR1I1 | Nuclear receptor subfamily 1 group I member 1 | VDR | VDR | Vitamin D3 receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group i > nuclear hormone receptor subfamily 1 group i member 1

Target Components

Component Description Relationship Accession
Vitamin D3 receptor SINGLE PROTEIN P11473

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL846 CALCITRIOL Vitamin D receptor agonist 4 FDA ISBN
CHEMBL1042 CHOLECALCIFEROL Vitamin D receptor agonist 4 PubMed PubMed
CHEMBL1536 ERGOCALCIFEROL Vitamin D receptor agonist 4 PubMed PubMed PubMed
CHEMBL1200622 PARICALCITOL Vitamin D receptor agonist 4 DailyMed
CHEMBL1200666 CALCIPOTRIENE Vitamin D receptor agonist 4 PubMed
CHEMBL1200810 DOXERCALCIFEROL Vitamin D receptor agonist 4 DailyMed PubMed PubMed PubMed
CHEMBL3544909 CALCIFEDIOL Vitamin D receptor agonist 4 PubMed
CHEMBL1908376 SEOCALCITOL Vitamin D receptor agonist 3 PubMed PubMed
CHEMBL3137307 PEFCALCITOL Vitamin D receptor agonist 3 Other Other
CHEMBL605525 DP001 Vitamin D receptor agonist 2 Other PubMed
CHEMBL2104955 BECOCALCIDIOL Vitamin D receptor agonist 2 Other
CHEMBL2105107 INECALCITOL Vitamin D receptor agonist 2 Other Other
CHEMBL2105705 LUNACALCIPOL Vitamin D receptor agonist 2 Other
CHEMBL3545094 Elocalcitol Vitamin D receptor agonist 2 PubMed PubMed
CHEMBL284121 ILX23-7553 Vitamin D receptor agonist 1 PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111424
Ensembl ENSG00000111424
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0043235 (receptor complex)
GO:0090575 (RNA polymerase II transcription factor complex)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0008434 (calcitriol receptor activity)
GO:0038186 (lithocholic acid receptor activity)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO:0046965 (retinoid X receptor binding)
GO:0070644 (vitamin D response element binding)
GO:1902098 (calcitriol binding)
GO:1902121 (lithocholic acid binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000902 (cell morphogenesis)
GO:0001501 (skeletal system development)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006816 (calcium ion transport)
GO:0006874 (cellular calcium ion homeostasis)
GO:0007165 (signal transduction)
GO:0007275 (multicellular organism development)
GO:0007595 (lactation)
GO:0008285 (negative regulation of cell proliferation)
GO:0009887 (organ morphogenesis)
GO:0010628 (positive regulation of gene expression)
GO:0010839 (negative regulation of keratinocyte proliferation)
GO:0010980 (positive regulation of vitamin D 24-hydroxylase activity)
GO:0038183 (bile acid signaling pathway)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045618 (positive regulation of keratinocyte differentiation)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046697 (decidualization)
GO:0050892 (intestinal absorption)
GO:0060058 (positive regulation of apoptotic process involved in mammary gland involution)
GO:0060558 (regulation of calcidiol 1-monooxygenase activity)
GO:0060745 (mammary gland branching involved in pregnancy)
GO:0070561 (vitamin D receptor signaling pathway)
Wikipedia Calcitriol_receptor

Target Cross References - Protein

canSAR P11473
CGD Vitamin D-dependent rickets, type 2A
Human Protein Atlas ENSG00000111424
IntAct P11473
Guide to Pharmacology 605
Open Targets ENSG00000111424
PharmGKB PA37301
Pharos P11473 (Tclin)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
UniProt B2R5Q1 G3V1V9 P11473 Q5PSV3

Target Cross References - Domain

InterPro IPR000324 (VitD_rcpt.)
IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3AX8 3AZ1 More...
CREDO 1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3AX8 3AZ1 More...
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