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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1977
Target Type SINGLE PROTEIN
Preferred Name Vitamin D receptor
Synonyms 1,25-dihydroxyvitamin D3 receptor | NR1I1 | Nuclear receptor subfamily 1 group I member 1 | VDR | VDR | Vitamin D3 receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group i > nuclear hormone receptor subfamily 1 group i member 1

Target Components

Component Description Relationship Accession
Vitamin D3 receptor SINGLE PROTEIN P11473

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1222 CALCIFEDIOL Vitamin D receptor agonist PubMed
CHEMBL1200666 CALCIPOTRIENE Vitamin D receptor agonist PubMed
CHEMBL846 CALCITRIOL Vitamin D receptor agonist FDA ISBN
CHEMBL1042 CHOLECALCIFEROL Vitamin D receptor agonist PubMed PubMed
CHEMBL1200810 DOXERCALCIFEROL Vitamin D receptor agonist DailyMed PubMed PubMed PubMed
CHEMBL1536 ERGOCALCIFEROL Vitamin D receptor agonist PubMed PubMed PubMed
CHEMBL1200622 PARICALCITOL Vitamin D receptor agonist DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111424
Ensembl ENSG00000111424
GO Cellular Component GO:0005654 (nucleoplasm)
GO Molecular Function GO:0003700 (sequence-specific DNA binding transcription factor activity)
GO:0003707 (steroid hormone receptor activity)
GO:0008270 (zinc ion binding)
GO:0008434 (vitamin D3 receptor activity)
GO:0046965 (retinoid X receptor binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0008285 (negative regulation of cell proliferation)
GO:0010980 (positive regulation of vitamin D 24-hydroxylase activity)
GO:0034339 (regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor)
GO:0046697 (decidualization)
GO:0060558 (regulation of calcidiol 1-monooxygenase activity)
Wikipedia Calcitriol_receptor

Target Cross References - Protein

canSAR P11473
CGD Vitamin D-dependent rickets, type 2A
Human Protein Atlas ENSG00000111424
IntAct P11473
Guide to Pharmacology 605 (Vitamin D receptor)
PharmGKB PA37301
Reactome REACT_71 (Gene Expression.)
UniProt B2R5Q1 P11473 Q5PSV3

Target Cross References - Domain

InterPro IPR000324 (VitD_rcpt.)
IPR000536 (Nucl_hrmn_rcpt_lig-bd_core.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Str_hrmn_rcpt.)
IPR008946 (Nucl_hormone_rcpt_ligand-bd.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3CS4 3CS6 3M7R
CREDO 1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3CS4 3CS6 3M7R
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