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Target Report Card

Target Name and Classification

Target ID CHEMBL1974
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase receptor FLT3
Synonyms CD135 | CD_antigen=CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Receptor-type tyrosine-protein kinase FLT3 | STK-1 | STK1 | Stem cell tyrosine kinase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase pdgfr family

Target Components

Component Description Relationship Accession
Receptor-type tyrosine-protein kinase FLT3 SINGLE PROTEIN P36888

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1567 SUNITINIB MALATE Tyrosine-protein kinase receptor FLT3 inhibitor 4 DailyMed
CHEMBL1200485 SORAFENIB TOSYLATE Tyrosine-protein kinase receptor FLT3 inhibitor 4 FDA
CHEMBL223360 LINIFANIB Tyrosine-protein kinase receptor FLT3 inhibitor 3 PubMed PubMed
CHEMBL522892 DOVITINIB Tyrosine-protein kinase receptor FLT3 inhibitor 3 PubMed
CHEMBL576982 QUIZARTINIB Tyrosine-protein kinase receptor FLT3 inhibitor 3 PubMed PubMed
CHEMBL603469 LESTAURTINIB Tyrosine-protein kinase receptor FLT3 inhibitor 3 PubMed
CHEMBL608533 MIDOSTAURIN Tyrosine-protein kinase receptor FLT3 inhibitor 3 PubMed PubMed
CHEMBL1287853 FEDRATINIB Tyrosine-protein kinase receptor FLT3 inhibitor 3 PubMed
CHEMBL2035187 PACRITINIB Tyrosine-protein kinase receptor FLT3 inhibitor 3 PubMed PubMed PubMed
CHEMBL2105728 CRENOLANIB Tyrosine-protein kinase receptor FLT3 inhibitor 3 Other PubMed
CHEMBL3301622 GILTERITINIB Tyrosine-protein kinase receptor FLT3 inhibitor 3 Other PubMed PubMed
CHEMBL3545026 Famitinib Tyrosine-protein kinase receptor FLT3 inhibitor 3 ClinicalTrials DOI PubMed
CHEMBL3545158 PLX-3397 Tyrosine-protein kinase receptor FLT3 inhibitor 3 PubMed
CHEMBL52885 ENMD-981693 Tyrosine-protein kinase receptor FLT3 inhibitor 2 Other
CHEMBL124660 TANDUTINIB Tyrosine-protein kinase receptor FLT3 inhibitor 2 Other PubMed PubMed
CHEMBL495727 AT-9283 Tyrosine-protein kinase receptor FLT3 inhibitor 2 PubMed
CHEMBL482968 ENMD-2076 Tyrosine-protein kinase receptor FLT3 inhibitor 2 Other PubMed PubMed
CHEMBL1230609 FORETINIB Tyrosine-protein kinase receptor FLT3 inhibitor 2 Other PubMed
CHEMBL1721885 SU-014813 Tyrosine-protein kinase receptor FLT3 inhibitor 2 PubMed
CHEMBL2103851 AMUVATINIB Tyrosine-protein kinase receptor FLT3 inhibitor 2 Other PubMed PubMed
CHEMBL3545160 SU-14813 Tyrosine-protein kinase receptor FLT3 inhibitor 2 PubMed
CHEMBL3545281 AKN-028 Tyrosine-protein kinase receptor FLT3 inhibitor 2 PubMed
CHEMBL3545285 XL-999 Tyrosine-protein kinase receptor FLT3 inhibitor 2 DOI Other PubMed
CHEMBL3545337 C-1311 Tyrosine-protein kinase receptor FLT3 inhibitor 2 PubMed PubMed
CHEMBL129857 AS-602868 Tyrosine-protein kinase receptor FLT3 inhibitor 1 PubMed
CHEMBL574738 AST-487 Tyrosine-protein kinase receptor FLT3 inhibitor 1 PubMed
CHEMBL1908397 KW-2449 Tyrosine-protein kinase receptor FLT3 inhibitor 1 PubMed PubMed
CHEMBL1944698 TG-02 Tyrosine-protein kinase receptor FLT3 inhibitor 1 PubMed
CHEMBL1980391 RG-1530 Tyrosine-protein kinase receptor FLT3 inhibitor 1 PubMed PubMed
CHEMBL3544962 CT-1578 Tyrosine-protein kinase receptor FLT3 inhibitor 1 PubMed PubMed
CHEMBL3545332 CEP-2563 Tyrosine-protein kinase receptor FLT3 inhibitor 1 PubMed
CHEMBL3545358 4SC-203 Tyrosine-protein kinase receptor FLT3 inhibitor 1 Other Other
CHEMBL3545427 CM-082 Tyrosine-protein kinase receptor FLT3 inhibitor 1 Other
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000122025
Ensembl ENSG00000122025
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043234 (protein complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0004896 (cytokine receptor activity)
GO:0005021 (vascular endothelial growth factor-activated receptor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0032403 (protein complex binding)
GO:0035259 (glucocorticoid receptor binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0001776 (leukocyte homeostasis)
GO:0002318 (myeloid progenitor cell differentiation)
GO:0002328 (pro-B cell differentiation)
GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0008284 (positive regulation of cell proliferation)
GO:0010243 (response to organonitrogen compound)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030097 (hemopoiesis)
GO:0030154 (cell differentiation)
GO:0030183 (B cell differentiation)
GO:0031100 (organ regeneration)
GO:0035726 (common myeloid progenitor cell proliferation)
GO:0038084 (vascular endothelial growth factor signaling pathway)
GO:0042531 (positive regulation of tyrosine phosphorylation of STAT protein)
GO:0042981 (regulation of apoptotic process)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043552 (positive regulation of phosphatidylinositol 3-kinase activity)
GO:0046651 (lymphocyte proliferation)
GO:0046777 (protein autophosphorylation)
GO:0071345 (cellular response to cytokine stimulus)
GO:0071385 (cellular response to glucocorticoid stimulus)
GO:0097028 (dendritic cell differentiation)
Wikipedia CD135

Target Cross References - Protein

canSAR P36888
Human Protein Atlas ENSG00000122025
IntAct P36888
Guide to Pharmacology 1807
Open Targets ENSG00000122025
PharmGKB PA28181
Pharos P36888 (Tclin)
Reactome R-HSA-449147 (Signaling by Interleukins.)
UniProt A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 P36888 Q13414

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001824 (Tyr_kinase_rcpt_3_CS.)
IPR007110 (Ig-like_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013151 (Immunoglobulin.)
IPR013783 (Ig-like_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR030118 (FLT3.)
Pfam PF00047 (ig)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1RJB 3QS7 3QS9 4RT7 4XUF
CREDO 1RJB 3QS7 3QS9 4RT7 4XUF
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