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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1968
Preferred Name Epoxide hydrolase 1
Synonyms EPHX | EPHX1 | EPOX | Epoxide hydratase | Epoxide hydrolase 1 | Microsomal epoxide hydrolase | mEH
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease sc clan > serine protease s33 family

Target Components

Component Description Relationship Accession
Epoxide hydrolase 1 SINGLE PROTEIN P07099

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143819
Ensembl ENSG00000143819
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004301 (epoxide hydrolase activity)
GO:0016787 (hydrolase activity)
GO:0033961 (cis-stilbene-oxide hydrolase activity)
GO Biological Process GO:0006725 (cellular aromatic compound metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0009636 (response to toxic substance)
GO:0014070 (response to organic cyclic compound)
GO:0019439 (aromatic compound catabolic process)
GO:0097176 (epoxide metabolic process)
Wikipedia EPHX1

Target Cross References - Protein

canSAR P07099
CGD Hypercholanemia, familial
Human Protein Atlas ENSG00000143819
IntAct P07099
Open Targets ENSG00000143819
PharmGKB PA27829
Reactome R-HSA-211945 (Phase I - Functionalization of compounds.)
UniProt B2R8N0 P07099 Q5VTJ6 Q9NP75 Q9NPE7 Q9NQU6 Q9NQU7 Q9NQU8 Q9NQU9 Q9NQV0 Q9NQV1 Q9NQV2

Target Cross References - Domain

InterPro IPR000639 (Epox_hydrolase-like.)
IPR010497 (Epoxide_hydro_N.)
IPR016292 (Epoxide_hydrolase.)
IPR029058 (AB_hydrolase.)
Pfam PF06441 (EHN)