ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL1963
Preferred Name Thyroid stimulating hormone receptor
Synonyms LGR3 | TSH-R | TSHR | Thyroid-stimulating hormone receptor | Thyrotropin receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > glycohormone receptor > glycohormone receptor

Target Components

Component Description Relationship Accession
Thyrotropin receptor SINGLE PROTEIN P16473

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201532 THYROTROPIN Thyroid stimulating hormone receptor agonist 4 PubMed
CHEMBL1201533 THYROTROPIN ALFA Thyroid stimulating hormone receptor agonist 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165409
Ensembl ENSG00000165409
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004996 (thyroid-stimulating hormone receptor activity)
GO:0005515 (protein binding)
GO:0008528 (G-protein coupled peptide receptor activity)
GO:0016500 (protein-hormone receptor activity)
GO:0038023 (signaling receptor activity)
GO:0044877 (macromolecular complex binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007267 (cell-cell signaling)
GO:0007399 (nervous system development)
GO:0008284 (positive regulation of cell proliferation)
GO:0009755 (hormone-mediated signaling pathway)
GO:0030819 (positive regulation of cAMP biosynthetic process)
GO:0038194 (thyroid-stimulating hormone signaling pathway)
GO:0045762 (positive regulation of adenylate cyclase activity)
GO:1904588 (cellular response to glycoprotein)
GO:1905229 (cellular response to thyrotropin-releasing hormone)
Wikipedia Thyrotropin_receptor

Target Cross References - Protein

canSAR P16473
CGD Hyperthyroidism, familial, gestational; Hypothyroidism, congenital, nongoitrous, 1; Thyroid dysgenesis, autosomal recessive
Human Protein Atlas ENSG00000165409
IntAct P16473
Guide to Pharmacology 255
Open Targets ENSG00000165409
PharmGKB PA37042
Pharos P16473 (Tclin)
Reactome R-HSA-375281 (Hormone ligand-binding receptors.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt A0PJU7 F5GYU5 G3V2A9 P16473 Q16503 Q8TB90 Q96GT6 Q9P1V4 Q9ULA3 Q9UPH3

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR002131 (Gphrmn_rcpt_fam.)
IPR002274 (TSH_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
IPR026906 (LRR_5.)
IPR032675 (LRR_dom_sf.)
Pfam PF00001 (7tm_1)
PF13306 (LRR_5)

Target Cross References - Structure

PDBe 2XWT 3G04