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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1962
Preferred Name GABA receptor alpha-1 subunit
Synonyms GABA(A) receptor subunit alpha-1 | GABRA1 | Gamma-aminobutyric acid receptor subunit alpha-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > gaba-a receptor

Target Components

Component Description Relationship Accession
Gamma-aminobutyric acid receptor subunit alpha-1 SINGLE PROTEIN P14867

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093872 GABA-A receptor; anion channel PROTEIN COMPLEX GROUP
CHEMBL1907597 GABA-A receptor; GABA-A site (alpha1/beta2 interface) PROTEIN COMPLEX
CHEMBL2095172 GABA-A receptor; alpha-1/beta-2/gamma-2 PROTEIN COMPLEX
CHEMBL2109244 GABA-A receptor; agonist GABA site PROTEIN COMPLEX GROUP
CHEMBL2109243 GABA-A receptor; benzodiazepine site PROTEIN COMPLEX GROUP
CHEMBL3885570 Gamma-aminobutyric acid receptor subunit alpha-1/ beta-1 PROTEIN COMPLEX
CHEMBL2111392 GABA A receptor alpha-1/beta-1/gamma-2 PROTEIN COMPLEX
CHEMBL2094121 GABA-A receptor; alpha-1/beta-3/gamma-2 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL262075 INDIPLON GABA receptor alpha-1 subunit positive allosteric modulator 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000022355
Ensembl ENSG00000022355
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030659 (cytoplasmic vesicle membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0034707 (chloride channel complex)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:1902710 (GABA receptor complex)
GO:1902711 (GABA-A receptor complex)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0004890 (GABA-A receptor activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005254 (chloride channel activity)
GO:0008144 (drug binding)
GO:0016917 (GABA receptor activity)
GO:0022851 (GABA-gated chloride ion channel activity)
GO:1904315 (transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)
GO Biological Process GO:0006811 (ion transport)
GO:0006821 (chloride transport)
GO:0007214 (gamma-aminobutyric acid signaling pathway)
GO:0034220 (ion transmembrane transport)
GO:0051932 (synaptic transmission, GABAergic)
GO:0060078 (regulation of postsynaptic membrane potential)
GO:0071420 (cellular response to histamine)
GO:1902476 (chloride transmembrane transport)
Wikipedia Gamma-aminobutyric_acid_receptor_subunit_alpha-1

Target Cross References - Protein

canSAR P14867
CGD Epilepsy, juvenile myoclonic, susceptibility to, 5; Epilepsy, childhood absence, susceptibility to, 4
Human Protein Atlas ENSG00000022355
IntAct P14867
Guide to Pharmacology 404
Open Targets ENSG00000022355
PharmGKB PA28489
Pharos P14867 (Tclin)
Reactome R-HSA-112314 (Neurotransmitter receptors and postsynaptic signal transmission.)
R-HSA-977441 (GABA A receptor activation.)
UniProt D3DQK6 P14867 Q8N629

Target Cross References - Domain

InterPro IPR001390 (GABAAa_rcpt.)
IPR005431 (GABBAa1_rcpt.)
IPR006028 (GABAA/Glycine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR036719 (Neuro-gated_channel_TM_sf.)
IPR036734 (Neur_chan_lig-bd_sf.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)