ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL1945
Preferred Name Melatonin receptor 1A
Synonyms MTNR1A | Mel-1A-R | Mel1a receptor | Melatonin receptor type 1A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine-derivative receptor (family a gpcr) > melatonin receptor

Target Components

Component Description Relationship Accession
Melatonin receptor type 1A SINGLE PROTEIN P48039

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094268 Melatonin receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000168412
Ensembl ENSG00000168412
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0008502 (melatonin receptor activity)
GO:0042562 (hormone binding)
GO:0097159 (organic cyclic compound binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007617 (mating behavior)
GO:0007623 (circadian rhythm)
GO:0030828 (positive regulation of cGMP biosynthetic process)
Wikipedia Melatonin_receptor_1A

Target Cross References - Protein

canSAR P48039
Human Protein Atlas ENSG00000168412
IntAct P48039
Guide to Pharmacology 287
Open Targets ENSG00000168412
PharmGKB PA31267
Pharos P48039 (Tclin)
Reactome R-HSA-373076 (Class A/1 (Rhodopsin-like receptors).)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt A0AVC5 B0M0L2 P48039

Target Cross References - Domain

InterPro IPR000025 (Melatonin_rcpt.)
IPR000276 (GPCR_Rhodpsn.)
IPR002278 (Mel_1A/1B_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
IPR027459 (Mel_rcpt_1.)
Pfam PF00001 (7tm_1)