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Target Report Card

Target Name and Classification

Target ID CHEMBL1937
Preferred Name Histone deacetylase 2
Synonyms HD2 | HDAC2 | Histone deacetylase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > histone deacetylase > hdac class i

Target Components

Component Description Relationship Accession
Histone deacetylase 2 SINGLE PROTEIN Q92769

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3430896 Histone deacetylase 1/2/3/6 PROTEIN FAMILY
CHEMBL3430897 Histone deacetylase 1/2/3 PROTEIN FAMILY
CHEMBL2093865 Histone deacetylase PROTEIN FAMILY
CHEMBL2111429 Histone deacetylase (HDAC1 and HDAC2) PROTEIN FAMILY
CHEMBL3885591 Histone deacetylase 2/Nuclear receptor corepressor 2 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL98 VORINOSTAT Histone deacetylase 2 inhibitor 4 DailyMed
CHEMBL272980 MOCETINOSTAT Histone deacetylase 2 inhibitor 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196591
Ensembl ENSG00000196591
GO Cellular Component GO:0000785 (chromatin)
GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0016580 (Sin3 complex)
GO:0016581 (NuRD complex)
GO:0032991 (macromolecular complex)
GO:0035098 (ESC/E(Z) complex)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000980 (RNA polymerase II distal enhancer sequence-specific DNA binding)
GO:0001103 (RNA polymerase II repressing transcription factor binding)
GO:0003682 (chromatin binding)
GO:0003723 (RNA binding)
GO:0004407 (histone deacetylase activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0016787 (hydrolase activity)
GO:0019213 (deacetylase activity)
GO:0019899 (enzyme binding)
GO:0031072 (heat shock protein binding)
GO:0031492 (nucleosomal DNA binding)
GO:0032041 (NAD-dependent histone deacetylase activity (H3-K14 specific))
GO:0033558 (protein deacetylase activity)
GO:0042826 (histone deacetylase binding)
GO:0043565 (sequence-specific DNA binding)
GO:0051059 (NF-kappaB binding)
GO:1990841 (promoter-specific chromatin binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001975 (response to amphetamine)
GO:0003300 (cardiac muscle hypertrophy)
GO:0006325 (chromatin organization)
GO:0006338 (chromatin remodeling)
GO:0006344 (maintenance of chromatin silencing)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0007596 (blood coagulation)
GO:0008284 (positive regulation of cell proliferation)
GO:0009913 (epidermal cell differentiation)
GO:0010718 (positive regulation of epithelial to mesenchymal transition)
GO:0010870 (positive regulation of receptor biosynthetic process)
GO:0010977 (negative regulation of neuron projection development)
GO:0016358 (dendrite development)
GO:0016575 (histone deacetylation)
GO:0031000 (response to caffeine)
GO:0032496 (response to lipopolysaccharide)
GO:0032732 (positive regulation of interleukin-1 production)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0032922 (circadian regulation of gene expression)
GO:0032967 (positive regulation of collagen biosynthetic process)
GO:0034605 (cellular response to heat)
GO:0035094 (response to nicotine)
GO:0042220 (response to cocaine)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0042493 (response to drug)
GO:0042531 (positive regulation of tyrosine phosphorylation of STAT protein)
GO:0042733 (embryonic digit morphogenesis)
GO:0043044 (ATP-dependent chromatin remodeling)
GO:0043066 (negative regulation of apoptotic process)
GO:0043392 (negative regulation of DNA binding)
GO:0043433 (negative regulation of sequence-specific DNA binding transcription factor activity)
GO:0045347 (negative regulation of MHC class II biosynthetic process)
GO:0045862 (positive regulation of proteolysis)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048149 (behavioral response to ethanol)
GO:0048511 (rhythmic process)
GO:0048714 (positive regulation of oligodendrocyte differentiation)
GO:0055093 (response to hyperoxia)
GO:0060789 (hair follicle placode formation)
GO:0061000 (negative regulation of dendritic spine development)
GO:0061029 (eyelid development in camera-type eye)
GO:0061198 (fungiform papilla formation)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0070932 (histone H3 deacetylation)
GO:0070933 (histone H4 deacetylation)
GO:0071300 (cellular response to retinoic acid)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1903351 (cellular response to dopamine)
GO:2000757 (negative regulation of peptidyl-lysine acetylation)
Wikipedia Histone_deacetylase_2

Target Cross References - Protein

canSAR Q92769
Human Protein Atlas ENSG00000196591
IntAct Q92769
Guide to Pharmacology 2616
Open Targets ENSG00000196591
PharmGKB PA29227
Reactome R-HSA-193670 (p75NTR negatively regulates cell cycle via SC1.)
R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-3214815 (HDACs deacetylate histones.)
R-HSA-427389 (ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.)
R-HSA-427413 (NoRC negatively regulates rRNA expression.)
R-HSA-4551638 (SUMOylation of chromatin organization proteins.)
R-HSA-6804758 (Regulation of TP53 Activity through Acetylation.)
R-HSA-73762 (RNA Polymerase I Transcription Initiation.)
R-HSA-8943724 (Regulation of PTEN gene transcription.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt B3KRS5 B4DL58 E1P561 Q5SRI8 Q5SZ86 Q8NEH4 Q92769

Target Cross References - Domain

InterPro IPR000286 (His_deacetylse.)
IPR003084 (His_deacetylse_1.)
IPR023696 (Ureohydrolase_dom_sf.)
IPR023801 (His_deacetylse_dom.)
IPR037138 (His_deacetylse_dom_sf.)
Pfam PF00850 (Hist_deacetyl)

Target Cross References - Structure