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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1935
Target Type SINGLE PROTEIN
Preferred Name Aldehyde dehydrogenase
Synonyms ALDH class 2 | ALDH-E2 | ALDH2 | ALDHI | ALDM | Aldehyde dehydrogenase, mitochondrial
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Aldehyde dehydrogenase, mitochondrial SINGLE PROTEIN P05091

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL964 DISULFIRAM Aldehyde dehydrogenase inhibitor DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111275
Ensembl ENSG00000111275
GO Cellular Component GO:0005759 (mitochondrial matrix)
GO Molecular Function GO:0004029 (aldehyde dehydrogenase (NAD) activity)
GO:0004030 (aldehyde dehydrogenase [NAD(P)+] activity)
GO:0009055 (electron carrier activity)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006069 (ethanol oxidation)
GO:0006805 (xenobiotic metabolic process)
GO:0042136 (neurotransmitter biosynthetic process)
Wikipedia ALDH2

Target Cross References - Protein

canSAR P05091
Human Protein Atlas ENSG00000111275
IntAct P05091
Guide to Pharmacology 2595 (aldehyde dehydrogenase 2 family (mitochondrial))
PharmGKB PA24696
Reactome REACT_13433 (Biological oxidations.)
REACT_13685 (Synaptic Transmission.)
UniProt P05091 Q03639 Q6IB13 Q6IV71

Target Cross References - Domain

InterPro IPR015590 (Aldehyde_DH_dom.)
IPR016160 (Ald_DH_CS.)
IPR016161 (Ald_DH/histidinol_DH.)
IPR016162 (Ald_DH_N.)
IPR016163 (Ald_DH_C.)
Pfam PF00171 (Aldedh)

Target Cross References - Structure

PDBe 1CW3 1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM 2ONM 2ONN 2ONO 2ONP 2VLE 3INJ 3INL 3N80 3N81 3N82 3N83
CREDO 1CW3 1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM 2ONM 2ONN 2ONO 2ONP 2VLE 3INJ 3INL 3N80 3N81 3N82 3N83
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