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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1926
Target Type SINGLE PROTEIN
Preferred Name Dihydrofolate reductase
Synonyms Dihydrofolate reductase
Organism Pneumocystis carinii
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Dihydrofolate reductase SINGLE PROTEIN P16184

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2097173 Dihydrofolate reductase; P. carinii vs rat SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2218878 TRIMETREXATE GLUCURONATE Dihydrofolate reductase inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Molecular Function GO:0004146 (dihydrofolate reductase activity)
GO:0016491 (oxidoreductase activity)
GO:0050661 (NADP binding)
GO Biological Process GO:0006545 (glycine biosynthetic process)
GO:0006730 (one-carbon metabolic process)
GO:0009165 (nucleotide biosynthetic process)
GO:0046654 (tetrahydrofolate biosynthetic process)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR P16184
UniProt P16184

Target Cross References - Domain

InterPro IPR001796 (DHFR_dom.)
IPR012259 (DHFR.)
IPR017925 (DHFR_CS.)
IPR024072 (DHFR-like_dom.)
Pfam PF00186 (DHFR_1)

Target Cross References - Structure

PDBe 1CD2 1DAJ 1DYR 1E26 1KLK 1LY3 1LY4 1S3Y 1VJ3 2CD2 2FZH 2FZI 3CD2 3NZ6 3NZ9 3NZA 3NZB 3NZC 3TD8 4CD2 4G8Z 4IXE 4IXF 4IXG More...
CREDO 1CD2 1DAJ 1DYR 1E26 1KLK 1LY3 1LY4 1S3Y 1VJ3 2CD2 2FZH 2FZI 3CD2 3NZ6 3NZ9 3NZA 3NZB 3NZC 3TD8 4CD2 4G8Z 4IXE 4IXF 4IXG More...
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