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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1918
Target Type SINGLE PROTEIN
Preferred Name Glutamate receptor ionotropic kainate 1
Synonyms EAA3 | Excitatory amino acid receptor 3 | GLUR5 | GRIK1 | GluK1 | GluR-5 | GluR5 | Glutamate receptor 5 | Glutamate receptor ionotropic, kainate 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > kainate receptor

Target Components

Component Description Relationship Accession
Glutamate receptor ionotropic, kainate 1 SINGLE PROTEIN P39086

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2109241 Glutamate receptor ionotropic kainate PROTEIN COMPLEX GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2103869 DASOLAMPANEL Glutamate receptor ionotropic kainate 1 antagonist 2 PubMed PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171189
Ensembl ENSG00000171189
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004970 (ionotropic glutamate receptor activity)
GO:0005216 (ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0015276 (ligand-gated ion channel activity)
GO:0015277 (kainate selective glutamate receptor activity)
GO:0038023 (signaling receptor activity)
GO Biological Process GO:0006811 (ion transport)
GO:0007215 (glutamate receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007399 (nervous system development)
GO:0007417 (central nervous system development)
GO:0034220 (ion transmembrane transport)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0051966 (regulation of synaptic transmission, glutamatergic)
GO:0060079 (excitatory postsynaptic potential)
Wikipedia GRIK1

Target Cross References - Protein

canSAR P39086
Human Protein Atlas ENSG00000171189
Guide to Pharmacology 450
Open Targets ENSG00000171189
PharmGKB PA28973
Pharos P39086 (Tclin)
Reactome R-HSA-451307 (Activation of Na-permeable kainate receptors.)
R-HSA-451308 (Activation of Ca-permeable Kainate Receptor.)
UniProt P39086 Q13001 Q86SU9

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10613 (Lig_chan-Glu_bd)

Target Cross References - Structure

PDBe 2ZNS 2ZNT 2ZNU 3FUZ 3FV1 3FV2 3FVG 3FVK 3FVN 3FVO 4MF3
CREDO 2ZNS 2ZNT 2ZNU 3FUZ 3FV1 3FV2 3FVG 3FVK 3FVN 3FVO 4MF3
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