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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1911
Preferred Name Succinate semialdehyde dehydrogenase
Synonyms ALDH5A1 | Aldehyde dehydrogenase family 5 member A1 | NAD(+)-dependent succinic semialdehyde dehydrogenase | SSADH | Succinate-semialdehyde dehydrogenase, mitochondrial
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Succinate-semialdehyde dehydrogenase, mitochondrial SINGLE PROTEIN P51649

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3542434 Aldehyde dehydrogenase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL433 VALPROATE SODIUM Succinate semialdehyde dehydrogenase inhibitor 4 PubMed
CHEMBL109 VALPROIC ACID Succinate semialdehyde dehydrogenase inhibitor 4 PubMed
CHEMBL2105613 DIVALPROEX SODIUM Succinate semialdehyde dehydrogenase inhibitor 4 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000112294
Ensembl ENSG00000112294
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005759 (mitochondrial matrix)
GO Molecular Function GO:0004777 (succinate-semialdehyde dehydrogenase (NAD+) activity)
GO:0009013 (succinate-semialdehyde dehydrogenase [NAD(P)+] activity)
GO:0016491 (oxidoreductase activity)
GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
GO:0042803 (protein homodimerization activity)
GO:0051287 (NAD binding)
GO Biological Process GO:0006006 (glucose metabolic process)
GO:0006083 (acetate metabolic process)
GO:0006105 (succinate metabolic process)
GO:0006536 (glutamate metabolic process)
GO:0006540 (glutamate decarboxylation to succinate)
GO:0006541 (glutamine metabolic process)
GO:0006650 (glycerophospholipid metabolic process)
GO:0006678 (glucosylceramide metabolic process)
GO:0006681 (galactosylceramide metabolic process)
GO:0006749 (glutathione metabolic process)
GO:0007417 (central nervous system development)
GO:0008152 (metabolic process)
GO:0009448 (gamma-aminobutyric acid metabolic process)
GO:0009450 (gamma-aminobutyric acid catabolic process)
GO:0009791 (post-embryonic development)
GO:0022904 (respiratory electron transport chain)
GO:0042135 (neurotransmitter catabolic process)
GO:0046459 (short-chain fatty acid metabolic process)
GO:0051289 (protein homotetramerization)
GO:0055114 (oxidation-reduction process)
Wikipedia Aldehyde_dehydrogenase_5_family,_member_A1

Target Cross References - Protein

canSAR P51649
CGD Succinic semialdehyde dehydrogenase deficiency
Human Protein Atlas ENSG00000112294
IntAct P51649
Guide to Pharmacology 2466
Open Targets ENSG00000112294
PharmGKB PA24702
Reactome R-HSA-916853 (Degradation of GABA.)
UniProt B2RD26 G5E949 P51649 Q546H9 Q8N3W6

Target Cross References - Domain

InterPro IPR010102 (Succ_semiAld_DH.)
IPR015590 (Aldehyde_DH_dom.)
IPR016160 (Ald_DH_CS_CYS.)
IPR016161 (Ald_DH/histidinol_DH.)
IPR016162 (Ald_DH_N.)
IPR016163 (Ald_DH_C.)
IPR029510 (Ald_DH_CS_GLU.)
Pfam PF00171 (Aldedh)

Target Cross References - Structure

PDBe 2W8N 2W8O 2W8P 2W8Q 2W8R
CREDO 2W8N 2W8O 2W8P 2W8Q 2W8R