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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1884
Target Type SINGLE PROTEIN
Preferred Name Nicotinic acetylcholine receptor alpha subunit
Synonyms Nicotinic acetylcholine receptor alpha subunit
Organism Ascaris suum
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > nicotinic acetylcholine receptor > nicotinic acetylcholine receptor alpha subunit

Target Components

Component Description Relationship Accession
Nicotinic acetylcholine receptor alpha subunit SINGLE PROTEIN O96760

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1770 LEVAMISOLE HYDROCHLORIDE Nicotinic acetylcholine receptor alpha subunit agonist 4 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004889 (acetylcholine-activated cation-selective channel activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0034220 (ion transmembrane transport)
GO:0098655 (cation transmembrane transport)

Target Cross References - Protein

canSAR O96760
UniProt O96760

Target Cross References - Domain

InterPro IPR002394 (Nicotinic_acetylcholine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR027361 (Acetylcholine_rcpt_TM.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)
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