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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1869
Target Type SINGLE PROTEIN
Preferred Name Ornithine decarboxylase
Synonyms ODC | ODC1 | Ornithine decarboxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > lyase

Target Components

Component Description Relationship Accession
Ornithine decarboxylase SINGLE PROTEIN P11926

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201037 EFLORNITHINE HYDROCHLORIDE HYDRATE Ornithine decarboxylase inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115758
Ensembl ENSG00000115758
GO Cellular Component GO:0005575 (cellular_component)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004586 (ornithine decarboxylase activity)
GO:0005515 (protein binding)
GO:0016829 (lyase activity)
GO:0016831 (carboxy-lyase activity)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0001822 (kidney development)
GO:0006521 (regulation of cellular amino acid metabolic process)
GO:0006595 (polyamine metabolic process)
GO:0006596 (polyamine biosynthetic process)
GO:0008284 (positive regulation of cell proliferation)
GO:0009446 (putrescine biosynthetic process)
GO:0009615 (response to virus)
GO:0033387 (putrescine biosynthetic process from ornithine)
GO:0042176 (regulation of protein catabolic process)
Wikipedia ODC1

Target Cross References - Protein

canSAR P11926
Human Protein Atlas ENSG00000115758
IntAct P11926
Guide to Pharmacology 1276
Open Targets ENSG00000115758
PharmGKB PA31897
Reactome R-HSA-350562 (Regulation of ornithine decarboxylase (ODC).)
R-HSA-351202 (Metabolism of polyamines.)
UniProt P11926 Q53TU3 Q6LDS9

Target Cross References - Domain

InterPro IPR000183 (Orn/DAP/Arg_de-COase.)
IPR002433 (Orn_de-COase.)
IPR009006 (Ala_racemase/Decarboxylase_C.)
IPR022643 (De-COase2_C.)
IPR022644 (De-COase2_N.)
IPR022653 (De-COase2_pyr-phos_BS.)
IPR022657 (De-COase2_CS.)
IPR029066 (PLP-binding_barrel.)
Pfam PF00278 (Orn_DAP_Arg_deC)
PF02784 (Orn_Arg_deC_N)

Target Cross References - Structure

PDBe 1D7K 2ON3 2OO0 4ZGY 5BWA
CREDO 1D7K 2ON3 2OO0 4ZGY 5BWA
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