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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1856
Preferred Name Steroid 5-alpha-reductase 2
Synonyms 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | S5AR 2 | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
3-oxo-5-alpha-steroid 4-dehydrogenase 2 SINGLE PROTEIN P31213

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363075 Steroid 5-alpha-reductase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL710 FINASTERIDE Steroid 5-alpha-reductase 2 inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000277893
Ensembl ENSG00000277893
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031090 (organelle membrane)
GO:0043025 (neuronal cell body)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0070852 (cell body fiber)
GO Molecular Function GO:0003865 (3-oxo-5-alpha-steroid 4-dehydrogenase activity)
GO:0009917 (sterol 5-alpha reductase activity)
GO:0016491 (oxidoreductase activity)
GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors)
GO:0030283 (testosterone dehydrogenase [NAD(P)] activity)
GO:0033218 (amide binding)
GO:0047751 (cholestenone 5-alpha-reductase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006694 (steroid biosynthetic process)
GO:0006702 (androgen biosynthetic process)
GO:0006706 (steroid catabolic process)
GO:0007267 (cell-cell signaling)
GO:0007548 (sex differentiation)
GO:0008202 (steroid metabolic process)
GO:0008209 (androgen metabolic process)
GO:0008584 (male gonad development)
GO:0010033 (response to organic substance)
GO:0014070 (response to organic cyclic compound)
GO:0018879 (biphenyl metabolic process)
GO:0018894 (dibenzo-p-dioxin metabolic process)
GO:0018963 (phthalate metabolic process)
GO:0021766 (hippocampus development)
GO:0021854 (hypothalamus development)
GO:0030154 (cell differentiation)
GO:0030539 (male genitalia development)
GO:0030540 (female genitalia development)
GO:0031667 (response to nutrient levels)
GO:0032354 (response to follicle-stimulating hormone)
GO:0033574 (response to testosterone)
GO:0042448 (progesterone metabolic process)
GO:0042493 (response to drug)
GO:0043434 (response to peptide hormone)
GO:0048545 (response to steroid hormone)
GO:0055114 (oxidation-reduction process)
GO:0060348 (bone development)
GO:0061370 (testosterone biosynthetic process)
Wikipedia SRD5A2

Target Cross References - Protein

canSAR P31213
CGD Steroid 5-alpha-reductase 2 deficiency
Human Protein Atlas ENSG00000277893
IntAct P31213
Guide to Pharmacology 2633
Open Targets ENSG00000277893
PharmGKB PA36113
Reactome R-HSA-193048 (Androgen biosynthesis.)
UniProt B2RE87 P31213 Q2M1R4 Q9BYE6

Target Cross References - Domain

InterPro IPR001104 (3-oxo-5_a-steroid_4-DH_C.)
IPR016636 (3-oxo-5-alpha-steroid_4-DH.)
Pfam PF02544 (Steroid_dh)