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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1850
Preferred Name Dopamine D5 receptor
Synonyms D(1B) dopamine receptor | D(5) dopamine receptor | D1beta dopamine receptor | DRD1B | DRD1L2 | DRD5 | Dopamine D5 receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > dopamine receptor

Target Components

Component Description Relationship Accession
D(1B) dopamine receptor SINGLE PROTEIN P21918

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096905 Dopamine receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000169676
Ensembl ENSG00000169676
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031526 (brush border membrane)
GO:0060170 (ciliary membrane)
GO:0097730 (non-motile cilium)
GO Molecular Function GO:0001588 (dopamine neurotransmitter receptor activity, coupled via Gs)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004952 (dopamine neurotransmitter receptor activity)
GO:0035240 (dopamine binding)
GO Biological Process GO:0001963 (synaptic transmission, dopaminergic)
GO:0001975 (response to amphetamine)
GO:0001992 (regulation of systemic arterial blood pressure by vasopressin)
GO:0001994 (norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)
GO:0006874 (cellular calcium ion homeostasis)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007191 (adenylate cyclase-activating dopamine receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007612 (learning)
GO:0007617 (mating behavior)
GO:0008306 (associative learning)
GO:0019226 (transmission of nerve impulse)
GO:0033861 (negative regulation of NAD(P)H oxidase activity)
GO:0042060 (wound healing)
GO:0042220 (response to cocaine)
GO:0045762 (positive regulation of adenylate cyclase activity)
GO:0045776 (negative regulation of blood pressure)
GO:0045924 (regulation of female receptivity)
GO:0046960 (sensitization)
GO:0060158 (phospholipase C-activating dopamine receptor signaling pathway)
GO:0060292 (long term synaptic depression)
GO:0071870 (cellular response to catecholamine stimulus)
GO:0072593 (reactive oxygen species metabolic process)
Wikipedia Dopamine_receptor_D5

Target Cross References - Protein

canSAR P21918
Human Protein Atlas ENSG00000169676
IntAct P21918
Guide to Pharmacology 218
Open Targets ENSG00000169676
PharmGKB PA148
Pharos P21918 (Tchem)
Reactome R-HSA-390651 (Dopamine receptors.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt B2R9S3 P21918 Q8NEQ8

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000497 (Dopamine_D5_rcpt.)
IPR000929 (Dopamine_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)