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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1836
Target Type SINGLE PROTEIN
Preferred Name Prostanoid EP4 receptor
Synonyms PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor EP4 subtype | Prostanoid EP4 receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > prostanoid receptor

Target Components

Component Description Relationship Accession
Prostaglandin E2 receptor EP4 subtype SINGLE PROTEIN P35408

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363068 Prostaglandin E2 receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL303960 RIVENPROST Prostanoid EP4 receptor agonist 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171522
Ensembl ENSG00000171522
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004955 (prostaglandin receptor activity)
GO:0004957 (prostaglandin E receptor activity)
GO:0005515 (protein binding)
GO Biological Process GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007254 (JNK cascade)
GO:0009612 (response to mechanical stimulus)
GO:0030278 (regulation of ossification)
GO:0032496 (response to lipopolysaccharide)
GO:0033624 (negative regulation of integrin activation)
GO:0042093 (T-helper cell differentiation)
GO:0050710 (negative regulation of cytokine secretion)
GO:0050715 (positive regulation of cytokine secretion)
GO:0050728 (negative regulation of inflammatory response)
GO:0050729 (positive regulation of inflammatory response)
GO:0051492 (regulation of stress fiber assembly)
GO:0060348 (bone development)
GO:0070371 (ERK1 and ERK2 cascade)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071380 (cellular response to prostaglandin E stimulus)
GO:2000420 (negative regulation of eosinophil extravasation)
Wikipedia EP4_receptor

Target Cross References - Protein

canSAR P35408
Human Protein Atlas ENSG00000171522
IntAct P35408
Guide to Pharmacology 343
Open Targets ENSG00000171522
PharmGKB PA289
Pharos P35408 (Tclin)
Reactome R-HSA-391908 (Prostanoid ligand receptors.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt P35408 Q3MJ87

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001244 (Prostglndn_DP_rcpt.)
IPR001758 (Prost_EP4_rcpt.)
IPR008365 (Prostanoid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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