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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1811
Target Type SINGLE PROTEIN
Preferred Name Prostanoid EP1 receptor
Synonyms PGE receptor EP1 subtype | PGE2 receptor EP1 subtype | PTGER1 | Prostaglandin E2 receptor EP1 subtype | Prostanoid EP1 receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > prostanoid receptor

Target Components

Component Description Relationship Accession
Prostaglandin E2 receptor EP1 subtype SINGLE PROTEIN P34995

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363068 Prostaglandin E2 receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL495 ALPROSTADIL Prostanoid EP1 receptor agonist 4 FDA ISBN

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160951
Ensembl ENSG00000160951
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004955 (prostaglandin receptor activity)
GO:0004957 (prostaglandin E receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0032496 (response to lipopolysaccharide)
Wikipedia EP1_receptor

Target Cross References - Protein

canSAR P34995
Human Protein Atlas ENSG00000160951
Guide to Pharmacology 340
Open Targets ENSG00000160951
PharmGKB PA286
Pharos P34995 (Tclin)
Reactome R-HSA-391908 (Prostanoid ligand receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
UniProt P34995 Q5U5U4 Q86UH3 Q86VB5 Q8NHB2

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000708 (Prostglndn_EP1_rcpt.)
IPR001244 (Prostglndn_DP_rcpt.)
IPR008365 (Prostanoid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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