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Target Report Card

Target Name and Classification

Target ID CHEMBL1795167
Target Type SINGLE PROTEIN
Preferred Name Toll-like receptor 4
Synonyms CD_antigen=CD284 | Lps | Tlr4 | Toll-like receptor 4
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > toll-like and il-1 receptors

Target Components

Component Description Relationship Accession
Toll-like receptor 4 SINGLE PROTEIN Q9QUK6

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038514 Toll-like receptor 4/MD-2/CD14 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005622 (intracellular)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031226 (intrinsic component of plasma membrane)
GO:0043235 (receptor complex)
GO:0045121 (membrane raft)
GO:0046696 (lipopolysaccharide receptor complex)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0001530 (lipopolysaccharide binding)
GO:0001875 (lipopolysaccharide receptor activity)
GO:0004888 (transmembrane signaling receptor activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0038023 (signaling receptor activity)
GO:0043548 (phosphatidylinositol 3-kinase binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0001774 (microglial cell activation)
GO:0002218 (activation of innate immune response)
GO:0002224 (toll-like receptor signaling pathway)
GO:0002322 (B cell proliferation involved in immune response)
GO:0002376 (immune system process)
GO:0002537 (nitric oxide production involved in inflammatory response)
GO:0002730 (regulation of dendritic cell cytokine production)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0002758 (innate immune response-activating signal transduction)
GO:0006691 (leukotriene metabolic process)
GO:0006954 (inflammatory response)
GO:0006979 (response to oxidative stress)
GO:0007165 (signal transduction)
GO:0007250 (activation of NF-kappaB-inducing kinase activity)
GO:0007252 (I-kappaB phosphorylation)
GO:0009617 (response to bacterium)
GO:0010572 (positive regulation of platelet activation)
GO:0010628 (positive regulation of gene expression)
GO:0014002 (astrocyte development)
GO:0030890 (positive regulation of B cell proliferation)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0032496 (response to lipopolysaccharide)
GO:0032497 (detection of lipopolysaccharide)
GO:0032609 (interferon-gamma production)
GO:0032689 (negative regulation of interferon-gamma production)
GO:0032700 (negative regulation of interleukin-17 production)
GO:0032707 (negative regulation of interleukin-23 production)
GO:0032715 (negative regulation of interleukin-6 production)
GO:0032720 (negative regulation of tumor necrosis factor production)
GO:0032722 (positive regulation of chemokine production)
GO:0032727 (positive regulation of interferon-alpha production)
GO:0032728 (positive regulation of interferon-beta production)
GO:0032729 (positive regulation of interferon-gamma production)
GO:0032732 (positive regulation of interleukin-1 production)
GO:0032733 (positive regulation of interleukin-10 production)
GO:0032735 (positive regulation of interleukin-12 production)
GO:0032755 (positive regulation of interleukin-6 production)
GO:0032757 (positive regulation of interleukin-8 production)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0032874 (positive regulation of stress-activated MAPK cascade)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0035666 (TRIF-dependent toll-like receptor signaling pathway)
GO:0042116 (macrophage activation)
GO:0042535 (positive regulation of tumor necrosis factor biosynthetic process)
GO:0043032 (positive regulation of macrophage activation)
GO:0043065 (positive regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043388 (positive regulation of DNA binding)
GO:0045084 (positive regulation of interleukin-12 biosynthetic process)
GO:0045087 (innate immune response)
GO:0045348 (positive regulation of MHC class II biosynthetic process)
GO:0045359 (positive regulation of interferon-beta biosynthetic process)
GO:0045362 (positive regulation of interleukin-1 biosynthetic process)
GO:0045368 (positive regulation of interleukin-13 biosynthetic process)
GO:0045410 (positive regulation of interleukin-6 biosynthetic process)
GO:0045416 (positive regulation of interleukin-8 biosynthetic process)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045471 (response to ethanol)
GO:0045576 (mast cell activation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046330 (positive regulation of JNK cascade)
GO:0050671 (positive regulation of lymphocyte proliferation)
GO:0050702 (interleukin-1 beta secretion)
GO:0050707 (regulation of cytokine secretion)
GO:0050718 (positive regulation of interleukin-1 beta secretion)
GO:0050727 (regulation of inflammatory response)
GO:0050729 (positive regulation of inflammatory response)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050829 (defense response to Gram-negative bacterium)
GO:0050965 (detection of temperature stimulus involved in sensory perception of pain)
GO:0050966 (detection of mechanical stimulus involved in sensory perception of pain)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051770 (positive regulation of nitric-oxide synthase biosynthetic process)
GO:0051930 (regulation of sensory perception of pain)
GO:0060729 (intestinal epithelial structure maintenance)
GO:0060907 (positive regulation of macrophage cytokine production)
GO:0070373 (negative regulation of ERK1 and ERK2 cascade)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070430 (positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)
GO:0070434 (positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)
GO:0070542 (response to fatty acid)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071223 (cellular response to lipoteichoic acid)
GO:0140052 (cellular response to oxidised low-density lipoprotein particle stimulus)
GO:1900017 (positive regulation of cytokine production involved in inflammatory response)
GO:1900227 (positive regulation of NLRP3 inflammasome complex assembly)
GO:1901224 (positive regulation of NIK/NF-kappaB signaling)
GO:1903223 (positive regulation of oxidative stress-induced neuron death)
GO:1903428 (positive regulation of reactive oxygen species biosynthetic process)
GO:1904467 (regulation of tumor necrosis factor secretion)
GO:1904646 (cellular response to beta-amyloid)

Target Cross References - Protein

canSAR Q9QUK6
IntAct Q9QUK6
Reactome R-MMU-140534 (Ligand-dependent caspase activation.)
R-MMU-166016 (Toll Like Receptor 4 (TLR4) Cascade.)
R-MMU-166166 (MyD88-independent TLR4 cascade.)
R-MMU-2562578 (TRIF-mediated programmed cell death.)
R-MMU-5686938 (Regulation of TLR by endogenous ligand.)
R-MMU-936964 (Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.)
R-MMU-937041 (IKK complex recruitment mediated by RIP1.)
R-MMU-937072 (TRAF6-mediated induction of TAK1 complex within TLR4 complex.)
UniProt Q9D691 Q9QUK6 Q9QZF5 Q9Z203

Target Cross References - Domain

InterPro IPR000157 (TIR_dom.)
IPR000483 (Cys-rich_flank_reg_C.)
IPR001611 (Leu-rich_rpt.)
IPR003591 (Leu-rich_rpt_typical-subtyp.)
IPR027168 (TLR4.)
IPR032675 (LRR_dom_sf.)
IPR035897 (Toll_tir_struct_dom_sf.)
Pfam PF01582 (TIR)
PF13855 (LRR_8)

Target Cross References - Structure

PDBe 2Z64 3VQ1 3VQ2 5IJB 5IJC 5IJD
CREDO 2Z64 3VQ1 3VQ2 5IJB 5IJC 5IJD
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