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Target Report Card

Target Name and Classification

Target ID CHEMBL1795129
Preferred Name Interleukin-6
Synonyms B-cell stimulatory factor 2 | BSF-2 | CDF | CTL differentiation factor | Hybridoma growth factor | IFN-beta-2 | IFNB2 | IL-6 | IL6 | Interferon beta-2 | Interleukin-6
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Interleukin-6 SINGLE PROTEIN P05231

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1743070 SILTUXIMAB Interleukin-6 inhibitor 4 FDA
CHEMBL1743050 OLOKIZUMAB Interleukin-6 inhibitor 3 PubMed
CHEMBL1743071 SIRUKUMAB Interleukin-6 inhibitor 3 PubMed
CHEMBL2108589 CLAZAKIZUMAB Interleukin-6 inhibitor 2 Other PubMed
CHEMBL2108591 ELSILIMOMAB Interleukin-6 inhibitor 2 PubMed
CHEMBL2109613 PF-04236921 Interleukin-6 inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136244
Ensembl ENSG00000136244
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005896 (interleukin-6 receptor complex)
GO:0009897 (external side of plasma membrane)
GO Molecular Function GO:0005102 (receptor binding)
GO:0005125 (cytokine activity)
GO:0005138 (interleukin-6 receptor binding)
GO:0005515 (protein binding)
GO:0008083 (growth factor activity)
GO Biological Process GO:0001781 (neutrophil apoptotic process)
GO:0001878 (response to yeast)
GO:0002262 (myeloid cell homeostasis)
GO:0002384 (hepatic immune response)
GO:0002446 (neutrophil mediated immunity)
GO:0002548 (monocyte chemotaxis)
GO:0002675 (positive regulation of acute inflammatory response)
GO:0002690 (positive regulation of leukocyte chemotaxis)
GO:0006469 (negative regulation of protein kinase activity)
GO:0006953 (acute-phase response)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0006959 (humoral immune response)
GO:0007568 (aging)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0008360 (regulation of cell shape)
GO:0009408 (response to heat)
GO:0009409 (response to cold)
GO:0009611 (response to wounding)
GO:0009612 (response to mechanical stimulus)
GO:0009617 (response to bacterium)
GO:0010574 (regulation of vascular endothelial growth factor production)
GO:0010628 (positive regulation of gene expression)
GO:0010888 (negative regulation of lipid storage)
GO:0010996 (response to auditory stimulus)
GO:0014070 (response to organic cyclic compound)
GO:0016049 (cell growth)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030168 (platelet activation)
GO:0031000 (response to caffeine)
GO:0031018 (endocrine pancreas development)
GO:0031175 (neuron projection development)
GO:0031667 (response to nutrient levels)
GO:0032494 (response to peptidoglycan)
GO:0032496 (response to lipopolysaccharide)
GO:0032722 (positive regulation of chemokine production)
GO:0032755 (positive regulation of interleukin-6 production)
GO:0032868 (response to insulin)
GO:0032966 (negative regulation of collagen biosynthetic process)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0033160 (positive regulation of protein import into nucleus, translocation)
GO:0034097 (response to cytokine)
GO:0035729 (cellular response to hepatocyte growth factor stimulus)
GO:0042060 (wound healing)
GO:0042102 (positive regulation of T cell proliferation)
GO:0042110 (T cell activation)
GO:0042127 (regulation of cell proliferation)
GO:0042493 (response to drug)
GO:0042517 (positive regulation of tyrosine phosphorylation of Stat3 protein)
GO:0042593 (glucose homeostasis)
GO:0042832 (defense response to protozoan)
GO:0042981 (regulation of apoptotic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043200 (response to amino acid)
GO:0043410 (positive regulation of MAPK cascade)
GO:0045079 (negative regulation of chemokine biosynthetic process)
GO:0045188 (regulation of circadian sleep/wake cycle, non-REM sleep)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045454 (cell redox homeostasis)
GO:0045599 (negative regulation of fat cell differentiation)
GO:0045630 (positive regulation of T-helper 2 cell differentiation)
GO:0045666 (positive regulation of neuron differentiation)
GO:0045669 (positive regulation of osteoblast differentiation)
GO:0045721 (negative regulation of gluconeogenesis)
GO:0045727 (positive regulation of translation)
GO:0045740 (positive regulation of DNA replication)
GO:0045765 (regulation of angiogenesis)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046427 (positive regulation of JAK-STAT cascade)
GO:0046677 (response to antibiotic)
GO:0046716 (muscle cell cellular homeostasis)
GO:0046849 (bone remodeling)
GO:0046888 (negative regulation of hormone secretion)
GO:0048635 (negative regulation of muscle organ development)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0050679 (positive regulation of epithelial cell proliferation)
GO:0050710 (negative regulation of cytokine secretion)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050829 (defense response to Gram-negative bacterium)
GO:0050830 (defense response to Gram-positive bacterium)
GO:0050871 (positive regulation of B cell activation)
GO:0051024 (positive regulation of immunoglobulin secretion)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051384 (response to glucocorticoid)
GO:0051592 (response to calcium ion)
GO:0051602 (response to electrical stimulus)
GO:0051607 (defense response to virus)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0051971 (positive regulation of transmission of nerve impulse)
GO:0060445 (branching involved in salivary gland morphogenesis)
GO:0060664 (epithelial cell proliferation involved in salivary gland morphogenesis)
GO:0070091 (glucagon secretion)
GO:0070102 (interleukin-6-mediated signaling pathway)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071347 (cellular response to interleukin-1)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0071549 (cellular response to dexamethasone stimulus)
GO:0071864 (positive regulation of cell proliferation in bone marrow)
GO:0072540 (T-helper 17 cell lineage commitment)
GO:1901215 (negative regulation of neuron death)
GO:2000366 (positive regulation of STAT protein import into nucleus)
GO:2000676 (positive regulation of type B pancreatic cell apoptotic process)
Wikipedia Interleukin_6

Target Cross References - Protein

canSAR P05231
Human Protein Atlas ENSG00000136244
IntAct P05231
Open Targets ENSG00000136244
PharmGKB PA198
Reactome R-HSA-1059683 (Interleukin-6 signaling.)
R-HSA-110056 (MAPK3 (ERK1) activation.)
R-HSA-112411 (MAPK1 (ERK2) activation.)
R-HSA-2559582 (Senescence-Associated Secretory Phenotype (SASP).)
R-HSA-6783783 (Interleukin-10 signaling.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt P05231 Q9UCU2 Q9UCU3 Q9UCU4

Target Cross References - Domain

InterPro IPR003574 (IL-6.)
IPR009079 (4_helix_cytokine-like_core.)
IPR012351 (4_helix_cytokine_core.)
IPR030473 (IL6/GCSF/MGF_CS.)
IPR030474 (IL-6/GCSF/MGF.)
Pfam PF00489 (IL6)

Target Cross References - Structure

PDBe 1ALU 1P9M 4CNI 4J4L 4NI7 4NI9 4O9H 4ZS7 5FUC