ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL1785
Preferred Name Endothelin receptor ET-B
Synonyms EDNRB | ET-B | ET-BR | ETRB | Endothelin receptor non-selective type | Endothelin receptor type B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > endothelin receptor

Target Components

Component Description Relationship Accession
Endothelin receptor type B SINGLE PROTEIN P24530

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096678 Endothelin receptor, ET-A/ET-B PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL23261 DARUSENTAN Endothelin receptor ET-B antagonist 3 PubMed
CHEMBL61780 TEZOSENTAN Endothelin receptor ET-B antagonist 3 PubMed PubMed PubMed
CHEMBL431651 ENRASENTAN Endothelin receptor ET-B antagonist 2 PubMed
CHEMBL2109282 RG-7636 Endothelin receptor ET-B binding agent 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136160
Ensembl ENSG00000136160
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031965 (nuclear membrane)
GO:0045121 (membrane raft)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004962 (endothelin receptor activity)
GO:0005515 (protein binding)
GO:0017046 (peptide hormone binding)
GO:0031702 (type 1 angiotensin receptor binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001755 (neural crest cell migration)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006885 (regulation of pH)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007194 (negative regulation of adenylate cyclase activity)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007399 (nervous system development)
GO:0007422 (peripheral nervous system development)
GO:0007497 (posterior midgut development)
GO:0007568 (aging)
GO:0008217 (regulation of blood pressure)
GO:0008284 (positive regulation of cell proliferation)
GO:0014043 (negative regulation of neuron maturation)
GO:0014070 (response to organic cyclic compound)
GO:0014826 (vein smooth muscle contraction)
GO:0019233 (sensory perception of pain)
GO:0019722 (calcium-mediated signaling)
GO:0019934 (cGMP-mediated signaling)
GO:0030318 (melanocyte differentiation)
GO:0031620 (regulation of fever generation)
GO:0032269 (negative regulation of cellular protein metabolic process)
GO:0032496 (response to lipopolysaccharide)
GO:0035645 (enteric smooth muscle cell differentiation)
GO:0035810 (positive regulation of urine volume)
GO:0035815 (positive regulation of renal sodium excretion)
GO:0042045 (epithelial fluid transport)
GO:0042310 (vasoconstriction)
GO:0042311 (vasodilation)
GO:0043066 (negative regulation of apoptotic process)
GO:0043473 (pigmentation)
GO:0048066 (developmental pigmentation)
GO:0048246 (macrophage chemotaxis)
GO:0048265 (response to pain)
GO:0048484 (enteric nervous system development)
GO:0050678 (regulation of epithelial cell proliferation)
GO:0051930 (regulation of sensory perception of pain)
GO:0060406 (positive regulation of penile erection)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0086100 (endothelin receptor signaling pathway)
GO:1990839 (response to endothelin)
Wikipedia Endothelin_receptor_type_B

Target Cross References - Protein

canSAR P24530
CGD Waardenburg syndrome type 4A; ABCD syndrome
Human Protein Atlas ENSG00000136160
IntAct P24530
Guide to Pharmacology 220
Open Targets ENSG00000136160
PharmGKB PA27618
Pharos P24530 (Tclin)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
UniProt A2A2Z8 A8K3T4 O15343 P24530 Q59GB1 Q5W0G9 Q8NHM6 Q8NHM7 Q8NHM8 Q8NHM9 Q9UD23 Q9UQK3

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000499 (Endthln_rcpt.)
IPR001112 (ETB_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure