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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1782
Target Type SINGLE PROTEIN
Preferred Name Farnesyl diphosphate synthase
Synonyms (2E,6E)-farnesyl diphosphate synthase | Dimethylallyltranstransferase | FDPS | FPP synthase | FPS | FPS | Farnesyl diphosphate synthase | Farnesyl pyrophosphate synthase | Geranyltranstransferase | KIAA1293
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > transferase

Target Components

Component Description Relationship Accession
Farnesyl pyrophosphate synthase SINGLE PROTEIN P14324

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL675 ALENDRONATE SODIUM Farnesyl diphosphate synthase inhibitor 4 ISBN PubMed PubMed PubMed PubMed
CHEMBL924 ZOLEDRONIC ACID Farnesyl diphosphate synthase inhibitor 4 FDA PubMed PubMed PubMed PubMed
CHEMBL1654 RISEDRONATE SODIUM Farnesyl diphosphate synthase inhibitor 4 DailyMed PubMed PubMed PubMed PubMed
CHEMBL3989401 PAMIDRONATE DISODIUM Farnesyl diphosphate synthase inhibitor 4 FDA PubMed PubMed PubMed PubMed PubMed
CHEMBL3989569 IBANDRONATE SODIUM Farnesyl diphosphate synthase inhibitor 4 DailyMed PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160752
Ensembl ENSG00000160752
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0003723 (RNA binding)
GO:0004161 (dimethylallyltranstransferase activity)
GO:0004337 (geranyltranstransferase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006694 (steroid biosynthetic process)
GO:0006695 (cholesterol biosynthetic process)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0008299 (isoprenoid biosynthetic process)
GO:0016032 (viral process)
GO:0016126 (sterol biosynthetic process)
GO:0033384 (geranyl diphosphate biosynthetic process)
GO:0045337 (farnesyl diphosphate biosynthetic process)
GO:0045540 (regulation of cholesterol biosynthetic process)

Target Cross References - Protein

canSAR P14324
Human Protein Atlas ENSG00000160752
IntAct P14324
Guide to Pharmacology 644
MICAD NBK24580 (Farnesyl diphosphate synthase)
Open Targets ENSG00000160752
PharmGKB PA28075
Reactome R-HSA-191273 (Cholesterol biosynthesis.)
R-HSA-2426168 (Activation of gene expression by SREBF (SREBP).)
UniProt D3DV91 E9PCI9 P14324 Q96G29

Target Cross References - Domain

InterPro IPR000092 (Polyprenyl_synt.)
IPR008949 (Isoprenoid_synthase_dom_sf.)
IPR033749 (Polyprenyl_synt_CS.)
Pfam PF00348 (polyprenyl_synt)

Target Cross References - Structure

PDBe 1YQ7 1YV5 1ZW5 2F7M 2F89 2F8C 2F8Z 2F92 2F94 2F9K 2OPM 2OPN 2QIS 2RAH 2VF6 3B7L 3CP6 3N1V 3N1W 3N3L 3N45 3N46 3N49 3N5H More...
CREDO 1YQ7 1YV5 1ZW5 2F7M 2F89 2F8C 2F8Z 2F92 2F94 2F9K 2OPM 2OPN 2QIS 2RAH 2VF6 3B7L 3CP6 3N1V 3N1W 3N3L 3N45 3N46 3N49 3N5H More...
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