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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1780
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 51
Synonyms CYP51 | CYPLI | Cytochrome P450 51 | Cytochrome P450-14DM | Cytochrome P450-LIA1 | ERG11 | ERG16 | Lanosterol 14-alpha demethylase | Sterol 14-alpha demethylase
Organism Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 51 > cytochrome p450 family 51a > cytochrome p450 51a1

Target Components

Component Description Relationship Accession
Lanosterol 14-alpha demethylase SINGLE PROTEIN P10613

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL91 MICONAZOLE Cytochrome P450 51 inhibitor 4 PubMed PubMed PubMed PubMed
CHEMBL104 CLOTRIMAZOLE Cytochrome P450 51 inhibitor 4 PubMed PubMed
CHEMBL106 FLUCONAZOLE Cytochrome P450 51 inhibitor 4 DailyMed
CHEMBL638 VORICONAZOLE Cytochrome P450 51 inhibitor 4 DailyMed
CHEMBL22587 ITRACONAZOLE Cytochrome P450 51 inhibitor 4 DailyMed
CHEMBL157101 KETOCONAZOLE Cytochrome P450 51 inhibitor 4 FDA ISBN
CHEMBL1306 TERCONAZOLE Cytochrome P450 51 inhibitor 4 DailyMed PubMed PubMed
CHEMBL1397 POSACONAZOLE Cytochrome P450 51 inhibitor 4 DailyMed
CHEMBL1559 MICONAZOLE NITRATE Cytochrome P450 51 inhibitor 4 PubMed PubMed PubMed PubMed
CHEMBL1200348 SULCONAZOLE NITRATE Cytochrome P450 51 inhibitor 4 KEGG
CHEMBL1200398 BUTOCONAZOLE NITRATE Cytochrome P450 51 inhibitor 4 FDA KEGG PubMed
CHEMBL1200438 TIOCONAZOLE Cytochrome P450 51 inhibitor 4 PubMed PubMed PubMed PubMed
CHEMBL1200725 SERTACONAZOLE NITRATE Cytochrome P450 51 inhibitor 4 FDA
CHEMBL1200836 OXICONAZOLE NITRATE Cytochrome P450 51 inhibitor 4 PubMed PubMed
CHEMBL1201049 ECONAZOLE NITRATE Cytochrome P450 51 inhibitor 4 PubMed PubMed
CHEMBL2105689 LULICONAZOLE Cytochrome P450 51 inhibitor 4 FDA
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008144 (drug binding)
GO:0008398 (sterol 14-demethylase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001766 (membrane raft polarization)
GO:0006629 (lipid metabolic process)
GO:0006694 (steroid biosynthetic process)
GO:0006696 (ergosterol biosynthetic process)
GO:0008202 (steroid metabolic process)
GO:0016126 (sterol biosynthetic process)
GO:0035690 (cellular response to drug)
GO:0036187 (cell growth mode switching, budding to filamentous)
GO:0055114 (oxidation-reduction process)
GO:0070988 (demethylation)

Target Cross References - Protein

canSAR P10613
UniProt A0A1D8PMZ1 P10613 Q5A524 Q92208

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002403 (Cyt_P450_E_grp-IV.)
IPR017972 (Cyt_P450_CS.)
IPR036396 (Cyt_P450_sf.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 5FSA 5TZ1 5V5Z
CREDO 5FSA 5TZ1 5V5Z
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