ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1777
Target Type SINGLE PROTEIN
Preferred Name Cytochrome b
Synonyms COB | CYTB | Complex III subunit 3 | Complex III subunit III | Cytochrome b | Cytochrome b-c1 complex subunit 3 | MT-CYB | MTCYB | Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Organism Plasmodium falciparum
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Cytochrome b SINGLE PROTEIN Q02768

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1450 ATOVAQUONE Cytochrome b inhibitor 4 DailyMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0070469 (respiratory chain)
GO Molecular Function GO:0009055 (electron carrier activity)
GO:0016491 (oxidoreductase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0022904 (respiratory electron transport chain)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR Q02768
UniProt Q02768

Target Cross References - Domain

InterPro IPR005797 (Cyt_b/b6_N.)
IPR005798 (Cyt_b/b6_C.)
IPR016174 (Di-haem_cyt_TM.)
IPR027387 (Cytb/b6-like.)
Pfam PF00032 (Cytochrom_B_C)
PF00033 (Cytochrome_B)
spacer
spacer